Propofol 목표농도조절주입 중 경비 또는 경구 기관내 삽관을 위한 remifentanil의 효과처농도 비교
Effect-site Concentration of Remifentanil for Nasotracheal versus Orotracheal Intubation during Propofol Target-controlled Infusion
- 주제(키워드) Remifentanil , Propofol , Orotracheal intubation , Nasotracheal intubation
- 발행기관 아주대학교 대학원
- 지도교수 김종엽
- 발행년도 2011
- 학위수여년월 2011. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000011257
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Background: The purpose of this study was to determine the effect-site concentrations of remifentanil required for acceptable nasotracheal (NT) intubation in adults after propofol target-controlled infusion (TCI) without neuromuscular blocking agent, and whether or not these concentrations differ from those for orotracheal (OT) intubation. Methods: Fifty patients were assigned to receive either OT intubation (OT group, n = 25) or NT intubation (NT group, n = 25). Anaesthesia was induced with propofol TCI at the effect-site concentration of 5.0 μg/ml. Two minutes later, the predetermined effect-site concentration of remifentanil was started (from 4.5 ng/ml) using Dixon’s up-and-down method. Tracheal intubation was performed during the remifentanil infusion 2 min after beginning. Acceptable intubation was defined as excellent or good intubating conditions. Results: EC50 ± SD of remifentanil in the OT and NT groups was 5.58 ± 0.75 ng/ml and 6.08 ± 0.75 ng/ml, respectively; there was no statistical significance between the groups (P = 0.277). Using isotonic regression, EC50 (95% CI) of remifentanil in the OT and NT groups was 5.00 (3.34-7.46) ng/ml and 5.75 (3.66-7.84) ng/mlv, respectively (P = 0.592). Conclusion: The effect-site concentration of remifentanil for acceptable NT intubation was 6.08 ng/ml in 50% of adults during propofol TCI at an effect-site concentration of 5.0 μg/ml without neuromuscular blocking agent. The predicted effect-site concentration of remifentanil for NT intubation was not different from OT intubation.
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ABSTRACTⅰ
TABLE OF CONTENTSⅱ
LIST OF FIGURES ⅲ
LIST OF TABLESⅳ
TEXTⅴ
Ⅰ. INTRODUCTION1
Ⅱ. METHODS 2
Ⅲ. RESULTS 6
Ⅳ. DISCUSSION 9
V. CONCLUSION 17
REFERENCES ⅵ
국문요약 ⅶ
