Design of combination preparations of drugs with different physical properties
- 주제(키워드) Oil-in-water emulsion , Spray dried microcapsules , Co-delivery of four drugs , Free-flowing powder properties , Solubility , Dissolution improvement
- 주제(DDC) 615.1
- 발행기관 아주대학교 일반대학원
- 지도교수 Beom-Jin Lee
- 발행년도 2026
- 학위수여년월 2026. 8
- 학위명 석사
- 학과 및 전공 일반대학원 약학과
- 실제URI http://www.dcollection.net/handler/ajou/000000036557
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
목차
1. Introduction 1
2. Materials ＆ Methods 9
2.1. Materials 9
2.2. O/W emulsion formulation 9
2.3. Particle size and PDI determination of o/w emulsions 12
2.4. Drug content 12
2.5. Powder characterization 13
2.5.1. Angle of repose 13
2.5.2. Carr's index and Hausner ratio determination of powders 13
2.5.3. Fourier-transform infrared spectroscopy （FT-IR） 14
2.5.4. Differential scanning calorimetry （DSC） 14
2.5.5. Field emission scanning electron microscope （FE-SEM） 14
2.5.6. Powder X-ray diffraction （PXRD） 14
2.6. In vitro dissolution test 14
2.7. Short-term stability study 15
2.8. HPLC analysis 15
3. Results ＆ Discussions 16
3.1. Particle size and PDI determination of spray-dried microcapsules encapsulating the four drugs 16
3.2. Drug content 19
3.3. Flowability of spray-dried microcapsules encapsulating o/w emulsion-based four drugs 23
3.4. Morphology of spray-dried o/w emulsions 25
3.5. Powder characterization 27
3.5.1. FT-IR analysis 27
3.5.2. DSC analysis 29
3.5.3. PXRD analysis 31
3.6. In vitro release test 33
3.7. Stability study 39
4. Conclusion 41
5. References 42
