Synergistic controlled release of donepezil for ultralong oral delivery
- 주제(키워드) Donepezil hydrochloride , Electrostatic complex , Sodium stearate , Polymeric matrix tablet , Process-modified powder , Ultralong controlled release
- 주제(DDC) 615.1
- 발행기관 아주대학교 일반대학원
- 지도교수 Beom-Jin Lee
- 발행년도 2026
- 학위수여년월 2026. 8
- 학위명 석사
- 학과 및 전공 일반대학원 약학과
- 실제URI http://www.dcollection.net/handler/ajou/000000036474
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
목차
1. Introduction 1
2. Materials and methods 5
2.1. Materials 5
2.2. Preparation of DPZ-SS complexes 5
2.2.1. Solubility of DPZ under different pH conditions 6
2.2.2. Preparation of DPZ-SS complexes 8
2.2.3. Determination of complexation yield 11
2.3. HPLC analysis 11
2.4. Physicochemical characterizations of DPZ-SS complexes 11
2.4.1. Solubility study 12
2.4.2. Fourier-transform infrared spectroscopy （FT-IR） 12
2.5. In vitro dissolution study of DPZ-SS complexes 12
2.6. Preparation of powdered DPZ-SS complex 13
2.7. In vitro dissolution study of DPZ-SS complex powder 15
2.8. Physicochemical characterization of DPZ-SS complex powder 15
2.8.1. Fourier-transform infrared spectroscopy （FT-IR） 15
2.8.2. Field emission scanning electron microscopy （FE-SEM） 15
2.8.3. High-power X-ray diffraction （HP-XRD） 16
2.8.4. Evaluation of powder properties 16
2.9. Preparation and characterization of polymeric matrix tablets containing DPZ and process-modified DPZ–SS （C5） 17
2.9.1. Preparation of polymeric matrix tablets containing DPZ and process-modified DPZ–SS （C5） 17
2.9.2. Evaluation of tablet physical properties and drug content 20
2.9.3. In vitro dissolution study of polymeric matrix tablets containing DPZ and process-modified DPZ–SS （C5） 20
3. Results and discussions 21
3.1. Solubility of DPZ under different pH conditions 21
3.2. Preparation and physicochemical characterization of DPZ-SS complexes 23
3.2.1. Preparation and complexation yield of DPZ-SS complexes 23
3.2.2. Solubility of DPZ–SS （C2, C3, and C5） in different pH conditions 25
3.2.3. Fourier-transform infrared spectroscopy （FT-IR） of DPZ and DPZ-SS complexes 27
3.3. In vitro dissolution study of DPZ-SS complexes 29
3.4. Process-modification of DPZ–SS （C5） 32
3.4.1. DPZ content of fumed silica-added DPZ–SS （C5） 32
3.4.2. In vitro dissolution study of process-modified DPZ–SS 34
3.5. Physicochemical characterization of process-modified DPZ-SS （C5） 36
3.5.1. FT-IR analysis 36
3.5.2. FE-SEM analysis 38
3.5.3. HP-XRD analysis 40
3.5.4. Powder properties 42
3.6. Evaluation of polymeric matrix tablets containing DPZ and process-modified DPZ–SS （C5） 44
3.6.1. Physical properties and drug content of polymeric matrix tablets 44
3.6.2. In vitro dissolution study of HPMC 4000-based matrix tablets . 46
3.6.3. In vitro dissolution study of polymeric matrix sustained-release tablets with different matrix formers 49
4. Conclusion 53
5. References 54
국문초록 59
