Stereoselective Total Synthesis of (+)-7-Deoxy-trans-Dihydronarciclasine
- 주제(키워드) (+)-7-Deoxy-trans-dihydronarciclasine , Total Synthesis , Stereoselective , Protecting Group-Free , Benzylic Allylaition
- 주제(DDC) 615.1
- 발행기관 아주대학교 일반대학원
- 지도교수 이동주
- 발행년도 2026
- 학위수여년월 2026. 2
- 학위명 석사
- 학과 및 전공 일반대학원 약학과
- 실제URI http://www.dcollection.net/handler/ajou/000000036102
- 본문언어 한국어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
A concise and protecting group-free stereoselective total synthesis of (+)-7-deoxy-trans- dihydronarciclasine, a potent anti-tumor isocarbostyril alkaloid natural product, has been accomplished in 10 steps in 6.3% overall yield from the readily available optically pure diol. Highlights of the synthesis comprise early-stage diastereoselective direct syn-allylation at C(10b), Felkin–Anh-controlled syn-vinylation to set the stereocenter at C(4), and a late-stage stereocontrolled installation of the diaxial diol at C(2)/C(3) of the C ring.
more목차
I. Introduction 1
II. Results and Discussion 3
III. Conclusion 12
IV. Experimental Section 13
1. Materials and Methods 13
2. Full Experimental Procedures and Analytical Data Compounds 15
V. References 24
VI. Appendix 27
