Studies Directed towards Stereoselective Total Syntheses of Musellarins A, B and C
- 주제(키워드) Total Syntheses , Musellarin
- 주제(DDC) 615.1
- 발행기관 아주대학교 일반대학원
- 지도교수 이동주
- 발행년도 2026
- 학위수여년월 2026. 2
- 학위명 석사
- 학과 및 전공 일반대학원 약학과
- 실제URI http://www.dcollection.net/handler/ajou/000000035995
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Synthetic studies directed toward a unified and divergent synthetic strategy for the tricyclic diarylheptanoid natural products (–)-musellarins A–C (1–3) are described, starting from a tetralone. The key feature of this strategy is a cyclic boronic ester-mediated diastereoselective alkenylation promoted by InBr3, efficiently constructing the linear diarylheptanoid backbone with high substrate-controlled stereochemical selectivity. Subsequent allylation and ring-closing metathesis (RCM) established the characteristic 2,6-dihydropyran-fused tricyclic framework of the musellarin congeners.
more목차
I. Introduction 1
II. Results and Discussion 3
III. Conclusion 6
IV. Experimental Section 7
1. Materials and Methods 7
2. Full Experimental Procedures and Analytical Data of Compounds 9
V. References 16
VI. Appendix 18
