Design and Characterization of 3D-Printed Bilayer Tablets via Hot-Melt Pneumatic Extrusion for Sequential Drug Release
- 주제(키워드) Three-dimensional printing technology , Bilayer tablet , Controlled release , Montelukast , Levocetirizine
- 주제(DDC) 651.1
- 발행기관 아주대학교 일반대학원
- 지도교수 Hyo-Eon Jin
- 발행년도 2026
- 학위수여년월 2026. 2
- 학위명 석사
- 학과 및 전공 일반대학원 바이오헬스규제과학과
- 실제URI http://www.dcollection.net/handler/ajou/000000035935
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
목차
1. Introduction 1
1.1 3D-Printed Manufacturing Strategies for Pharmaceutical Dosage Forms . 1
1.2 Hot-Melt Pneumatic Extrusion (HMPE) Technology 2
1.3 Controlled Release Strategy in Bilayer Tablets 3
1.4 Research Objectives 4
2. Materials and Methods 8
2.1 Materials 8
2.2 Design of 3D-Printed Tablets 9
2.3 Preparation of HMPE 11
2.4 Evaluation of the Mechanical Properties of Tablets 11
2.5 Ultra High-Performance Liquid Chromatography (UHPLC) Analysis 12
2.6 Content Uniformity 12
2.7 Differential Scanning Calorimetry (DSC) 13
2.8 Powder X-ray Diffraction (PXRD) 14
2.9 Scanning Electron Microscope (SEM) 14
2.10 In Vitro Dissolution Test 14
2.11 Statistical analysis 15
3. Results and Discussion 16
3.1 Optimization of Polymer Combinations for 3D-Printed Tablets. 16
3.2 Optimization of Printing Parameters 22
3.3 Mechanical Properties of 3D-Printed Bilayer Tablet 24
3.4 Content Uniformity 27
3.5. Differential Scanning Calorimetry (DSC) 29
3.6 Powder X-ray Diffraction (PXRD) 32
3.7 Surface Morphology of 3D-Printed Tablets 35
3.8 In Vitro Dissolution Profile of 3D-Printed Tablets 38
4. Conclusion 44
References 46
국문요약 53
