The Cut-off Value of Serum Triglyceride/ High-Density Lipoprotein Cholesterol Ratio of High Pericardial Adipose Tissue
- 주제(키워드) Adipose Tissue , Pericardium , Triglycerides , HDL cholesterol , Metabolic Syndrome
- 주제(DDC) 610
- 발행기관 아주대학교 일반대학원
- 지도교수 주남석
- 발행년도 2026
- 학위수여년월 2026. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000035846
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Background: Recently, both the triglyceride/high-density lipoprotein cholesterol (TG/HDL) ratio and pericardial adipose tissue (PAT) have emerged as important indicators associated with metabolic syndrome (MS). We aimed to evaluate the relationship between the TG/HDL ratio and PAT. Methods: We retrospectively analyzed data from 627 patients who underwent coronary multidetector computed tomography to assess metabolic parameters. Subjects were stratified into two groups based on the PAT volume cut-off associated with MS, specifically 142.2cm³, and metabolic parameters were compared between these groups. The TG/HDL ratio was divided into tertiles according to the logarithm of TG/HDL, and differences in PAT-related parameters among tertiles were assessed using analysis of variance. Logistic regression was performed to estimate the odds ratios (ORs) for high PAT ( ≥ 142.2cm ³ ) across tertiles and receiver operating characteristic (ROC) analysis was performed to determine the optimal TG/HDL ratio cut-off for linking with high PAT. Results: The mean TG/HDL ratio in the group with high PAT was 3.6. The TG/HDL ratio demonstrated strong positive correlations with several metabolic parameters. Individuals in the higher Log(TG/HDL) tertiles exhibited a greater prevalence of metabolic disturbances, including increased PAT, and displayed higher ORs for having high PAT (OR=3.51 in the second tertile and OR=3.26 in the third tertile) after adjusting for age, sex, smoking, hypertension, type 2 diabetes, dyslipidemia status. ROC analysis identified a TG/HDL ratio of 1.92 (P<0.001) as the threshold for elevated PAT. Conclusion: The TG/HDL ratio is positively correlated with high PAT volume and the TG/HDL ratio cut-off for associated with high PAT was determined to be 1.92.
more목차
I. Introduction 1
II. Methods 3
A. Subjects and Data Collection 3
B. Measurement 3
1. Definition of Metabolic Syndrome 3
2. Anthropometric and Laboratory Measurements 4
3. Measurement of pericardial adipose tissue 5
4. Statistics 5
III. Results 7
IV. Discussion 9
V. References 23
