Influence of the antidiabetic effect of vitexicarpin on the pharmacokinetics of sitagliptin in streptozotocin-induced diabetic rats
- 주제(키워드) Vitexicarpin , Sitagliptin , Pharmacokinetics , Streptozotocin , Diabetes mellitus
- 주제(DDC) 651.1
- 발행기관 아주대학교 일반대학원
- 지도교수 김소희
- 발행년도 2026
- 학위수여년월 2026. 2
- 학위명 석사
- 학과 및 전공 일반대학원 바이오헬스규제과학과
- 실제URI http://www.dcollection.net/handler/ajou/000000035613
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
목차
I. INTRODUCTION 1
Ⅱ. METHOD 4
A. Chemicals 4
B. Animals 4
C. Induction of Diabetes mellitus 5
D. Preliminary study 5
E. Intravenous and oral administration of sitagliptin 6
F. HPLC analysis of sitagliptin 7
G. LC-MS/MS analysis of sitagliptin 8
H. Pharmacokinetics analysis 10
I. Measurement of Vmax, Km and CLint in hepatic and intestinal microsomes 10
J. Immunoblot analysis 11
K. Statistical analysis 12
III. RESULTS 13
A. Analytical performance of LC-MS/MS assay 13
B. Preliminary study 15
C. Pharmacokinetics of sitagliptin after intravenous administration 21
D. Pharmacokinetics of sitagliptin after oral administration 24
E. Measurement of Vmax, Km and CLint in hepatic and intestinal microsomes 27
F. Protein production of CYP isozymes 29
Ⅳ. DISCUSSION 31
Ⅴ. CONCLUSION 37
Reference 38
KOREAN ABSTRACT 43
