Stage related lesion volume and lesion bone density changes after treatment of MRONJ
MRONJ 치료 후 병기별 병변 부피 및 병변 골밀도 변화
- 주제(키워드) Medication-related osteonecrosis of jaws , MRONJ staging , cone-beam computed tomography , bone density
- 주제(DDC) 617.6
- 발행기관 아주대학교 임상치의학대학원
- 지도교수 이정근
- 발행년도 2026
- 학위수여년월 2026. 2
- 학위명 석사
- 학과 및 전공 임상치의학대학원 임상치의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000035549
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Objectives: This retrospective study evaluated changes in lesion volume and bone density in medication-related osteonecrosis of the jaw (MRONJ) using cone-beam computed tomography (CBCT) at different disease stages following conservative and surgical treatment. Additionally, the study analyzed the correlations between these changes and influencing factors. Materials and Methods: A total of 54 patients (mean [SD] age, 75.43 [7.44] years) diagnosed with stage 0, 1, 2, or 3 MRONJ, according to the American Association of Oral and Maxillofacial Surgeons’ guidelines, were included. Pre- and post-treatment CBCT images were superimposed to identify the lesion locations, and lesions were segmented manually using ITK-SNAP software. Lesion volume and mean bone density before and after treatment were calculated. Results: Overall, the average lesion volume decreased by 35.23% and the average bone density increased by 6.88%. Stage 0–1 lesions showed a 16.96% reduction in volume and a 16.77% reduction in bone density, while stage 2–3 lesions exhibited a 45.98% reduction in volume and a 20.8% increase in bone density (P<0.05). There was significant correlations between %∆V and the drug holiday duration (r = –0.346, P = 0.001), interval between T0 and T1 (r = –0.302, P = 0.026), and treatment outcome (r = –0.358, P = 0.008). Conclusion: Treatment of MRONJ resulted in significant reduction of lesion volume with stage 2-3 MRONJ lesions demonstrated greater improvement in bone quality compared to stage 0-1. Notably, conservative treatment may potentially benefit from a longer drug holiday, while surgical treatment showed positive effects on both soft and hard tissues in stage 2–3 lesions, regardless of the drug holiday duration.
more목차
Ⅰ. INTRODUCTION 1
Ⅱ. MATERIALS AND METHODS 4
A. Patients 4
B. CBCT examination 6
C. Segmentation and measurements 7
D. Statistical analysis 11
Ⅲ. RESULTS 12
Ⅳ. DISCUSSION 19
Ⅴ. CONCLUSION 23
REFERENCES 24
국문요약 29
