Prolonged Parenteral Nutrition Increases the Risk of Comorbidities in Very-Low-Birth-Weight Infants : A Prospective National Cohort Study in South Korea
- 주제(키워드) very-low-birth-weight infants , parenteral nutrition , periventricular leukomalacia , bronchopulmonary dysplasia , retinopathy of prematurity
- 주제(DDC) 610
- 발행기관 아주대학교 일반대학원
- 지도교수 이장훈
- 발행년도 2026
- 학위수여년월 2026. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000035530
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Background/Objectives: There has been an increase in the incidence of co morbidities among very-low-birth-weight infants (VLBWIs), including periventricular leukomalacia (PVL), bronchopulmonary dysplasia (BPD), and retinopathy of prematurity (ROP). Parenteral nutrition is essential for very-low-birth-weight infants (VLBWIs) who are born with a birth weight of less than 1500 g, but a longer duration of parenteral nutrition is known to have a risk of comorbidity, such as ROP. This study aims to investigate the relationship between the duration of parenteral nutrition and the comorbidities of the VLBWIs. Methods: Using the prospective cohort of Korean neonatal network, we analyzed the perinatal and postnatal data before discharge of the total 2490 subjects born in 2021 and 2022. The primary outcomes were the diagnoses of PVL, BPD, and ROP. The secondary outcomes were the severity of BPD and ROP, treatment of ROP, and proposing the predictive model of comorbidities using the duration of parenteral nutrition. Results: This study found that prolonged parenteral nutrition exceeding 28 days was associated with a higher risk of PVL (odds ratio [OR] 1.71, 95% confidence interval [CI] [1.11, 2.64], p = 0.002) and BPD (OR 1.51, 95% CI [1.10, 2.08], p = 0.011). Furthermore, an intermediate duration of parenteral nutrition was found to be significantly associated with an increased risk of ROP in male subjects. Additionally, a prolonged duration of parenteral nutrition was observed to be linked to greater severity of BPD. Predictive models incorporating the duration of parenteral nutrition demonstrated a high degree of explanatory power in relation to both BPD and ROP. Conclusions: Longer duration of parenteral nutrition has a risk of critical comorbidities in VLBWIs. The nutrition strategy for shorter parenteral nutrition should be encouraged for the prevention of comorbidities. Keywords: very-low-birth-weight infants; parenteral nutrition; periventricular leukomalacia; bronchopulmonary dysplasia; retinopathy of prematurity
more목차
Ⅰ. Introduction 1
Ⅱ. Materials and Methods 2
A. Study Design and Data Source 2
B. Study Population 3
C. Data Collection 4
D. Outcomes 5
E. Statistical Analysis 5
Ⅲ. Results 7
A. Characteristics of Cohort and Their Comorbidities 7
B. Comparison of Confounder by Duration of Parenteral Nutrition 8
C. Duration of Parenteral Nutrition and the Risk of PVL 9
D. Duration of Parenteral Nutrition and the Risk of BPD 10
E. Duration of Parenteral Nutrition and the Risk of ROP 11
Ⅳ. Discussion 14
Ⅴ. Conclusions 19
References 20
