Comparison of neonatal outcomes between multiples and singletons among very low birth weight infants : The Korean Neonatal Network cohort study
- 주제(키워드) Very low birth weight infants , Multiples , Singletons , Korean Neonatal Network detabase
- 발행기관 아주대학교 일반대학원
- 지도교수 이장훈, 노오규, 최서희
- 발행년도 2025
- 학위수여년월 2025. 8
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000034950
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Objective: To compare neonatal outcomes between multiples and singletons among very low birth weight infants, this was a prospective cohort study that was conducted by collecting data registered in the Korean Neonatal Network database. Methods: From January 2013 to December 2016, there were 8265 infants in the Korean Neonatal Network database, and 2958 of them were from multiples. Among them, 2636 infants were twins, 308 infants were triplets, and 14 infants were quadruplets. Maternal and neonatal variables including and mortality major morbidity were compared. Finally, the predicted rates of major morbidity between singletons and multiples. Results: Multiples had higher gestational age, birth weight, Apgar score at 5min, rates of cesarean section and artificial reproductive technology but lower maternal hypertension, oligohydramnios, chorioamnionitis rates and Clinical Risk Index for Babies scores II without base excess than the singletons. In univariate analysis, multiples had a lower incidence of respiratory distress syndrome, bronchopulmonary dysplasia, and sepsis. The mortality rate was not significantly different for overall gestational ages except for those born at ≤26weeks of gestation. In multivariate logistic analysis, the incidences of intraventricular hemorrhage (grade ≥3), and retinopathy of prematurity requiring treatment were significantly higher than the singletons. Conclusions: Mortality was not significantly different between multiples and singletons according to overall gestational age, except for multiples born at ≤26weeks. A significant higher risk of intraventricular hemorrhage and retinopathy of prematurity requiring treatment was found in multiples. A new strategy to improve the mortality of immature multiples born at ≤26weeks of gestation should be developed.
more목차
Ⅰ. Introduction 1
Ⅱ. Material and methods 2
A. Study population 2
B. Definitions 2
C. Data analysis 3
D. Statistical analysis 3
E. Statement of ethics 3
Ⅲ. Results 4
Ⅳ. Discussion 6
A. Limitation 8
Ⅴ. Conclusions 8
Reference 9
