Minimally Invasive Surgery versus Open Surgery in Advanced Stage Endometrial Cancer
- 주제(키워드) Advanced endometrial cancer , Staging surgery , Minimally invasive surgery , Open surgery
- 주제(DDC) 610
- 발행기관 아주대학교 일반대학원
- 지도교수 Suk-Joon Chang
- 발행년도 2025
- 학위수여년월 2025. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000034479
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Minimally Invasive Surgery versus Open Surgery in Advanced Stage Endometrial Cancer Aim: Staging surgery in early stage endometrial cancer has been shown to be feasible and safe with minimally invasive surgery (MIS) in many previous studies. However, there is limited literature on MIS’s safety in advanced stages. This study aims to identify factors associated with survival in stage III endometrial cancer and investigate survival differences based on surgical approach. Methods: Patients with stage III endometrial cancer who underwent staging surgery from March 2002 to March 2023 were included in this study. Various clinicopathological features, disease-free survival (DFS), and overall survival (OS) were evaluated. Results: Among the 79 patients included in this study, 20 patients underwent MIS (25.3%) and 59 patients underwent open surgery (74.7%). The open surgery group had a higher prevalence of aggressive histology, a higher median pretreatment CA- 125 level, and a greater number of harvested lymph nodes compared to the MIS group. 5-year OS and DFS was higher in the open surgery group than in the MIS group (DFS: 67.9% vs 59.9%, p=0.046, OS:74.3 vs 50.6%, p=0.008). In multivariate analysis, younger than 55 years old (OR, 2.778; 95% CI, 1.078-7.156; p=0.034) and open surgery (OR, 3.671; 95% CI, 1.581-8.522; p=0.002) was related to improved Conclusions: Open staging surgery showed better survival outcomes when compared to MIS in stage III endometrial cancer patients in our study. For patients who are older than 55 years old and have aggressive histology in endometrial biopsy, considering open surgery may help improve their prognosis, even if preoperative MRI suggests early-stage endometrial cancer. _________________________________________________________________________ Key Words: Advanced endometrial cancer; Staging surgery; Minimally invasive surgery; Open surgery
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