아주대학교

목차

1. Introduction 1
2. Materials and Methods 13
2.1. Materials 13
2.2. Solubility studies 14
2.3. BTC-excipient compatibility studies 14
2.4. Preparation of BTC-loaded tablet formulations 17
2.5. In vitro buoyancy studies 22
2.6. Swelling and erosion studies by gravimetric analysis of GRTs and CRTs tablet 22
2.7. In vitro dissolution studies 24
2.8. Release kinetics and mechanism of BTC-loaded tablets and CRTs tablets 24
2.9. Water penetration 26
2.10. Field emission scanning electron microscopy (FE-SEM) 26
2.11. HPLC analysis 27
2.12. Fourier transform-infrared (FT-IR) spectroscopy analysis 27
2.13. In vivo pharmacokinetic studies 28
2.13.1. Animals 28
2.13.2. Experimental design 28
2.13.3. UPLC – MS/MS analysis 31
2.13.4. Statistical analysis 32
3. Results and Discussion 33
3.1. Solubility studies 33
3.2. BTC-excipient compatibility studies 36
3.3. In vitro buoyancy studies 38
3.4. Swelling and erosion studies by gravimetric analysis of GRTs and CRTs tablet 41
3.5. In vitro dissolution studies 50
3.6. Drug release kinetic modeling 55
3.7. Release-modulating mechanism – Relationship between dissolution, matrix, erosion, and water uptake 60
3.8. Field Emission Scanning Electron Microscopy (FE-SEM) 65
3.9. Fourier-transform infrared (FT-IR) spectroscopy analysis 67
3.10. In vivo pharmacokinetic studies in beagle dogs 71
4. Conclusions 82
5. Graphical abstract 84
6. References 85