아주대학교

목차

1. Introduction 1
2. Materials and Methods 6
2.1 Materials 6
2.2 Synthesis of oxidized alginate 6
2.3 Fourier-transform infrared spectroscopy (FTIR) 7
2.4 Fabrication of gelatin-OA hydrogels 7
2.5 Swelling ratio 8
2.6 Scanning electron microscopy (SEM) 8
2.7 Mesh size and rheology of hydrogels 8
2.8 Vial inversion test and adhesion test 9
2.9 Preparation of chitosan-coated lipid nanoparticles 9
2.10 Particle size, PDI, and zeta-potential 10
2.11 Stability test of P2 and P2-3 10
2.12 Cultivation of L. plantarum 10
2.13 Preparation of hyaluronic acid-coated L. plantarum 11
2.14 Cultivation of hyaluronic acid-coated L. plantarum 11
2.15 In vivo wound healing assay in diabetic rats 11
2.16 Statistics 13
3. Results 14
3.1 Characterization of OA 14
3.2 Fabrication of hydrogels 14
3.3 Swelling ratio of hydrogels 14
3.4 SEM 15
3.5 Mesh size and micro-rheology 15
3.6 Adhesiveness and vial inversion test 16
3.7 Characterization of chitosan-coated lipid nanoparticles encapsulated EGF: Particle size, zeta-potential, PDI 16
3.8 Stability test of P2 and P2-3 17
3.9 Stability test of hyaluronic acid-coated L. plantarum 17
3.10 Wound healing assay in diabetic rats 17
4. Discussion 19
5. Conclusion 22
References 32
-국문요약- 38