Monocyte Count and Systemic Immune-Inflammation Index Score as Predictors of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage
- 주제(키워드) Monocytes , Systemic immune-inflammation index score , Delayed cerebral ischemia , Aneurysmal subarachnoid hemorrhage
- 주제(DDC) 610
- 발행기관 아주대학교 일반대학원
- 지도교수 임용철
- 발행년도 2024
- 학위수여년월 2024. 8
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000034002
- 본문언어 한국어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Objectives Delayed cerebral ischemia (DCI) is a major cause of disability in patients who survive aneurysmal subarachnoid hemorrhage (aSAH). Systemic inflammatory markers, such as peripheral leukocyte count and systemic inflammatory index score, have been considered predictors of DCI in previous studies. This study aims to investigate which systemic biomarkers are significant predictors of DCI. Methods We conducted a retrospective, observational, signle-center study of 170 patients with SAH admitted We analyzed 3 4 and 5 7 days after admission. The DCI and non-DCI group were compared. Variables showing statistical significance in (P < 0.05) were entered into a multivariable regression model. Results hydrocephalus, intraventricular hemorrhage, and infection showed statistical significance (P < 0.05) on a univariable logistic regression. Lymphocyte and monocyte count systemic inflammatory index scores and C-reactive protein levels on days 3 4, and leukocyte neutrophil counts on days 5 7 exhibited statistical significance on the univariable logistic regression. Multivariable logistic regression analysis revealed that monocyte count at admission (odds ratio [OR] = 1.64; 95% confidence interval [CI], 1.04 2.65; P = 0.036) and systemic inflammatory index score at days 3 4 (OR = 1.55; 95% CI, 1.02 2.47; P = 0.049) were independent predictors of DCI. Conclusions Monocyte count at admission and systemic inflammatory index score 3 4 days after rupture are independent predictors of clinical deterioration caused by DCI after aSAH. Peripheral monocytosis may be the primer for at days 3 4 can promptly represent the propagated systemic immune reaction toward DCI. Keywords: Monocyte count, Systemic immune-inflammation index score, Delayed cerebral ischemia, Aneurysmal subarachnoid hemorrhage
more목차
I. INTRODUCTION 1
II. METHODS 3
A. Study Design and Patient population 3
B. Demographics and Clinical Parameters 3
C. Laboratory Parameters 4
D. Definition and Assessment of Delayed Cerebral Ischemia 4
E. Statistical Analyses 4
III. RESULTS 6
IV. DISCUSSION 8
V. CONCLUSIONS 11
VI. REFERENCES 20
VII. STATEMENTS AND DECLARATION 23
