검색 상세

Relationship between the dynamics of non-alcoholic fatty liver disease and incident diabetes mellitus

  • 한지은 (Ji Eun Han, 아주대학교 일반대학원)

초록/요약

Relationship between Dynamics of Non-alcoholic Fatty Liver Disease and Incident Diabetes Mellitus Background & Aim: This study evaluated the association between the pattern of changes in non-alcoholic fatty liver disease (NAFLD) over time and the risk of incident diabetes mellitus (DM). Methods: In total, 3047 subjects without underlying DM were followed up for 14 years from the Anseong-Ansan cohort. NAFLD status was determined biennially using the hepatic steatosis index (HSI), and subjects were clustered into seven groups according to changes in HSI, body mass index (BMI), and homeostatic model assessment of insulin resistance (HOMA-IR): none, persistent, transient, transient resolved, resolved, incident, and recurrent NAFLD (Groups 1–7, respectively). Predictive abilities were compared between the dynamics of HSI and single time points. Results: Regarding the changes in HSI, the risk of incident DM was highest in Group 2 (hazard ratio [HR] 2.710; P<0.001), followed by Groups 7 (HR 2.062; P<0.001) and 3 (HR 1.559; P=0.027). The predictive ability for DM was powerful in order of HOMA-IR, HSI and BMI. The dynamics of NAFLD were less predictive of incident DM than single time– point NAFLD. Conclusion: NAFLD is more useful than BMI in predicting incident DM. However, NAFLD status at single time points can better predict incident DM than dynamic changes in HSI. Keywords : Non-alcoholic fatty liver disease; Hepatic steatosis index; Diabetes mellitus;

more

목차

I. INTRODUCTION 1
II. METHODS 3
A. Study population 3
B. Definition of terms 4
C. Anthropometric and laboratory evaluation 6
D. Statistical analysis 7
III. RESULTS 8
A. Baseline characteristics of the subjects 8
B. Risk factors for developing incident DM 9
C. Comparison of the risk of developing incident DM according to change pattern of HSI and metabolic associated fatty liver disease (MAFLD) 10
D. Comparison of the risk of developing incident DM according to change pattern of BMI and HOMA-IR, Fibrosis-4 score 11
E. Comparison of discriminatory ability for predicting incident DM among the change patterns of HSI, BMI and HOMA-IR over time 12
F. Comparison of discriminatory ability for predicting incident DM among the change patterns of HSI and MAFLD over time in MAFLD population 13
G. Comparison of discriminatory ability for predicting incident DM between change pattern of HSI over time and NAFLD development at a single time point 14
IV. DISCUSSION 26
V. CONCLUSION 31
VI. REFERENCE 32
VII. SUPPLEMENTARY APPENDIX 38
VIII. 국문요약 48

more
반출 Meta View 목록