Development of a Transient Shuttle-Based Probe for Chronic Monitoring of Wide Brain Areas
- 주제(키워드) transient electronics , variable stiffness , neural probes , mesh electronics
- 주제(DDC) 570
- 발행기관 아주대학교 일반대학원
- 지도교수 Eun Jeong Lee
- 발행년도 2024
- 학위수여년월 2024. 8
- 학위명 석사
- 학과 및 전공 일반대학원 의생명과학과
- 실제URI http://www.dcollection.net/handler/ajou/000000033873
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
목차
Ⅰ. INTRODUCTION 1
A. Monitoring methods of electrical brain activity 1
B. Evolution and challenges of MEAs 3
C. Enhancing chronic brain implants: Advances in flexible mesh probes 5
D. Soluble materials for deep brain implantation of flexible electronics 7
E. Aims 8
Ⅱ. MATERIALS AND METHODS 10
A. Procedure for fabricating the transient shuttle-based probe 10
B. Decreased rigidity of the transient shuttle-based probe 13
C. Brain tissue phantom using agarose gel 14
D. In vivo test using mice 14
E. Micro-CT imaging 15
F. Analysis method for Micro-CT Image 16
G. Tissue preparation and immunostaining 18
H. Analysis of immunostaining image 19
Ⅲ. RESULTS 21
A. Concept for the research and fabrication methods. 21
B. Mechanical characteristics of transient shuttle-based probes during insertion 32
C. Mechanical characteristics of transient shuttle-based probes during withdrawal. 39
D. In vivo test using mouse brains for insertion and withdrawal. 51
E. Histology studies of chronic implantation of the transient shuttle-based probe in mouse brains. 60
Ⅳ. CONCLUSIONS 69
REFERENCES 71
국문 요약 79
