Total synthesis of Malabaricones A-D
- 주제(키워드) diarylnonanoid , malabaricones A–D , Sonogashira cross-coupling , Pd/C , hydrogenation , hydrogenolysis
- 주제(DDC) 615.1
- 발행기관 아주대학교 일반대학원
- 지도교수 Dongjoo Lee
- 발행년도 2024
- 학위수여년월 2024. 2
- 학위명 석사
- 학과 및 전공 일반대학원 약학과
- 실제URI http://www.dcollection.net/handler/ajou/000000033771
- 본문언어 한국어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
The highly concise and efficient route to access naturally occurring diarylnonanoid malabaricones A–D has been developed starting from three commercially available building blocks in four steps. The key features of this approach is the Sonogashira cross-coupling to incorporate structurally diverse aryl groups and Pd/C-promoted concomitant hydrogenation and hydrogenolysis in a single operation to accomplish the total synthesis of the malabaricone family. This unified and divergent approach enables the preparation of novel structurally diverse malabaricone libraries
more목차
I. Introduction 1
II. Results and Discussion 5
III. Conclusion 10
IV. Experimental Section 11
1. Materials and Methods 11
2. Full Experimental Procedures and Analytical Data of Compounds 13
V. References 28
VI. Appendix 31
