Non-invasive PCO₂ Monitoring during Polysomnography: Transcutaneous versus End-tidal Measurement
- 주제(키워드) hypoventilation , carbon dioxide , sleep apnea syndromes , capnography , blood gas monitoring (transcutaneous)
- 주제(DDC) 610
- 발행기관 아주대학교 일반대학원
- 지도교수 김현준
- 발행년도 2024
- 학위수여년월 2024. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000033521
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Monitoring of arterial partial pressure of carbon dioxide during polysomnography can be used to diagnose sleep-related hypoventilation. However, sampling arterial blood is very invasive and cannot be routinely applied. The objectives of this study were to monitor transcutaneous and end-tidal partial pressures of carbon dioxide simultaneously during polysomnography, determine the advantages and disadvantages of each method, and identify relevant factors that can affect the results. This cross-sectional study enrolled 55 adults who underwent polysomnography at the Ajou University Hospital Sleep Center between February 2021 and September 2022. They were volunteers who spontaneously breathed room air. Polysomnography reports, including those of carbon dioxide monitoring, of all participants were reviewed and analyzed by sleep experts. Generalized Estimation Evaluation, Bon Ferroni Post Hoc and multivariable regression analysis were used for statistical analysis. Throughout all sleep stages, the mean, highest, and lowest values of end-tidal and transcutaneous partial pressure of carbon dioxide showed significant differences. The mean transcutaneous partial pressure was higher than the mean end-tidal partial pressure by 2.54 mmHg. The apnea index, apnea-hypopnea index, and height were significant factors affecting the difference between the mean transcutaneous and end-tidal partial pressure of carbon dioxide. As the obstructive sleep apnea grade increased, the mean end-tidal carbon dioxide partial pressure value decreased. Two patients had hypoventilation; one met the criteria based on the transcutaneous partial pressure of carbon dioxide and the other met those based on the end-tidal partial pressure of carbon dioxide. In conclusion, during diagnostic sleep studies, our study suggest the application of both transcutaneous and end-tidal measurements for stable and accurate monitoring of partial pressure of carbon dioxide and complementary analysis. Considerations that should be preceded when using both methods as surrogates for arterial partial pressure of carbon dioxide during polysomnography include factors such as physical characteristics, clinical history, breathing status, and obstructive sleep apnea severity.
more목차
Abstract I
Table of Contents III
List of Figures IV
List of Tables V
I. Introduction 1
II. Methods 3
A. Ethics statements 3
B. Study design and subjects 3
C. Data collection 3
D. Statistical analysis 4
III. Results 5
IV. Discussion 7
A. Principal results and strengths of the study 7
B. Measuring PEtCO₂ 8
C. Measuring PTcCO₂ 9
D. Comparison with other studies 10
V. Conclusions 12
VI. Figures 13
VII. Tables 20
References 29
국문초록 32
