Study on clinicopathological characteristics of pituitary adenomas according to types of transcription factors
- 주제(키워드) pituitary adenoma , pituitary neoplasm , neuroendocrine tumors , transcription factors
- 주제(DDC) 570
- 발행기관 아주대학교 일반대학원
- 지도교수 Jang Hee Kim
- 발행년도 2024
- 학위수여년월 2024. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의생명과학과
- 실제URI http://www.dcollection.net/handler/ajou/000000033470
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
A tumor arising from the pituitary gland, located in the lower part of the central brain, is called a pituitary adenoma. Pituitary adenomas are generally benign tumors, and their clinical and pathological classification has traditionally been based on factors such as tumor size, the presence of clinical symptoms due to hormone secretion, and the type of hormone produced by the adenoma. However, recent World Health Organization (WHO) tumor classifications have introduced new criteria based on the expression patterns of transcription factors and cell origin. This study aimed to analyze the clinical characteristics of patients diagnosed with pituitary adenoma at Ajou University Hospital and to reclassify them based on the new transcription factor-based classification criteria proposed by the WHO. A total of 555 specimens from patients diagnosed with pituitary adenoma were retrospectively reviewed, and among them, tissue microarrays (TMA) were constructed for 362 patients. Recurrence occurred in 22 patients, and hormone-induced clinical symptoms appeared in the late recurrence group. Upon applying the new classification criteria, gonadotroph tumors were the most frequently observed subtype, with 180 cases. Rare tumors such as thyrotroph tumor, acidophil stem cell tumor and Crooke cell tumor were not observed. Patients showing immune negative reactions for all hormones and transcription factors were classified as null cell tumors, with a total of 18 cases. The results of this study provide insights into the clinical and pathological characteristics of pituitary adenomas in Koreans.
more목차
I. Introduction 1
II. Materials & Methods 3
A. Pituitary adenoma samples from patients 3
B. Production tissue microarray (TMA) 3
C. Immunohistochemistry 4
D. Western blot 5
E. IHC data analysis 7
F. Statistical analysis 7
III. Results 8
A. Clinical data of pituitary adenoma patients 8
B. Histological variations in samples from pituitary adenoma patients 14
C. HE stains patterns of pituitary adenoma 14
D. Hormone immunostaining results and gender, age distribution characteristics 18
E. Transcription factor immunostaining results and gender, age distribution characteristics 27
F. New classification of pituitary neuroendocrine tumors by 2022 WHO 34
G. Pit-1 lineage PitNETs 37
H. Tpit lineage PitNETs 44
I. SF-1 lineage PitNETs 46
J. PitNETs with no distinct cell lineage 47
K. Unclassifiable cases 49
L. New classification results of Ajou University Hospital pituitary adenoma patients under WHO classification 2022 49
IV. Discussion 51
V. Conclusion 57
VI. References 58
