Protein-Based Multifunctional Electronic Tattoos for Drug Delivery and Charge Storage
약물전달과 축전소자 응용을 위한 단백질 기반 다기능 전자문신 연구.
- 주제(키워드) E-tattoo , silk protein , CNT , bio capacitor , drug delivery
- 주제(DDC) 621.042
- 발행기관 아주대학교
- 지도교수 Sang Woon Lee
- 발행년도 2023
- 학위수여년월 2023. 2
- 학위명 석사
- 학과 및 전공 일반대학원 에너지시스템학과
- 실제URI http://www.dcollection.net/handler/ajou/000000032469
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Epidermal electronic systems for detecting electrophysiological signals, sensing, therapy, and drug delivery are at the forefront of man-machine interfaces in healthcare. The development of multifunctional bio applications with minimal invasiveness, biocompatibility, and stable electrical performance under various mechanical deformations of biological tissues remains a challenge. Using natural silk protein and carbon nanotubes (CNTs), an epidermal electronic tattoo (E-tattoo) system for multifunctional applications is proposed in this study. These challenges can be addressed by dispersing highly conductive CNTs on biocompatible silk nanofibrous networks with porous surfaces to build ultrathin electronic patches that adhere to the skin. A bio capacitor that exhibits frequency-dependent capacitances (up to 350 pF at 5 kHz), a stimulator for drug delivery, and real-time charge generation with the touch of a finger are part of a system that incorporates optically active heaters, a bio capacitor, and a stimulator for drug delivery. Using an SNF/CNT-based triboelectric nanogenerator E-tattoo, multiple bare-finger touches can generate charges that are stored in the capacitor (0.23 V for 200 touches). This device is better than a commercial band-aid at transmitting water vapor at 115.04 g m-2 d-1, due to the micro/nanopores in the NF network. It is also capable of sensing ethanol. Multicomponent integrated ultrathin and epidermal electronics can be constructed using the developed E-tattoo capacitor. A next-generation electronic platform for wearables and epidermal bio applications can be developed using this E-tattoo strategy.
more목차
1) Introduction 1
2) Methods and preparation 3
2.1.Preparation of silk protein solution 3
2.2.Preparation of nanofibers using Electrospinning 3
2.3.Preparation of CNT ink 4
2.4.Preparation of Ultrathin transdermal patch (E-tattoo) 4
2.5.Preparation of drug loaded transdermal patch 4
2.6.Fabrication of SNF-CNT/PVANF/ CNT-SNF biopolymer capacitor 4
2.7.Electrical and optical measurement method 5
3) Results 6
3.1.Morphology and optical properties 6
3.1.1. Morphology of E-tattoo 6
3.1.2. Morphology of capacitor 8
3.2.Optical heating behavior of the E-tattoo 10
3.3.Application in drug delivery 13
3.4.Capacitive measurements 16
3.4.1. Electrical and capacitive characteristics of the SNF-CNT/PVA/CNT-SNF capacitor 16
3.4.2. Temperature-dependent capacitive characteristics of the SNF-CNT/PVA/CNT-SNF capacitor 20
3.4.3. Demonstrating the multifunctionality of the SNF-CNT/PVA/CNT-SNF capacitor 22
4) Conclusion 28
5) Reference 29
