Inhibition of cannabinoid 1 receptor ameliorates oxazolone-induced contact hypersensitivity in mice
- 주제(키워드) Contact hypersensitivity , Cannabinoid 1 receptor , Toll like receptor , MyD88 , NLRP3 inflammasome
- 주제(DDC) 547
- 발행기관 아주대학교
- 지도교수 김욱
- 발행년도 2022
- 학위수여년월 2022. 2
- 학위명 석사
- 학과 및 전공 일반대학원 분자과학기술학과
- 실제URI http://www.dcollection.net/handler/ajou/000000031555
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
목차
I. INTRODUCTION 1
II. MATERIALS and METHODS 4
1. Materials 4
2. Mice 6
3. OXA-induced contact hypersensitivity mouse model 6
4. Histological analysis 7
5. Statistical analysis 7
III. RESULTS 8
1. Inhibition of CB1R with rimonabant alleviates OXA-induced CHS in the mouse model 8
2. Rimonabant improves CHS independently of TLR-4 14
3. Rimonabant alleviates CHS dependently of TLR-2/4 22
4. Rimonabant ameliorates CHS in a MyD88-dependent manner 30
5. Rimonabant attenuates the CHS response via inhibition of NLRP3 inflammasome 36
IV. DISCUSSION 44
V. REFERENCE 47
VI. ABSTRACT IN KOREAN (국문초록) 51
