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Prognostic reappraisal of postoperative carcinoembryonic antigen in T1-2N0 colorectal cancer

초록/요약

Background/Aim: The purpose of this study was to compare the prognostic value of preoperative carcinoembryonic antigen (CEA), preoperative CEA/tumor size and postoperative CEA in stage I colorectal cancer. Patients and Methods: We analyzed a total of 305 consecutive stage I colorectal cancer patients who underwent a radical surgery at our Department. The patients were divided into low and high preoperative CEA groups, low and high preoperative CEA/tumor size groups, and low and high postoperative CEA groups according to the optimal cut-off values. Results: Multivariate analysis showed that postoperative CEA was independently associated with OS and DFS. However, the preoperative CEA and preoperative CEA/tumor size were not. Conclusion: The prognostic value of postoperative CEA is better than preoperative CEA and preoperative CEA/tumor size in patients with stage I colorectal cancer. Moreover, the common 5 ng/ml cut-off was not optimal for risk stratification in stage I colorectal cancer.

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목차

Ⅰ. INTRODUCTION 1
Ⅱ. PATIENTS AND METHODS 4
A. Patients 5
B. Data collection 5
C. Statistical analysis 7
Ⅲ. RESULTS 9
A. Clinicopathological features 10
B. Survival analysis based on the preoperative and postoperative CEA cut-off value of 5.0 ng/ml 13
C. Re-determined the cut-off value of preoperative and postoperative CEA 15
D. Survival analysis according to the new cut-off values 17
E. Univariate and multivariate analyses for OS and DFS 20
F. Survival analysis of postoperative CEA in colon and rectal cancer 26
G. Survival analysis based on CEA changes 28
H. The relationship between postoperative CEA and clinicopathological features 31
Ⅳ. DISCUSSION 34
Ⅴ. CONCLUSION 40
REFERENCES 42

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