Preparation of URL-recognizing QR-coded Orodispersible Film Using 3D Printing
- 주제(키워드) 3D printing , Hot melt extrusion , Orodispersible film , QR code , Paliperidone palmitate
- 주제(DDC) 615.1
- 발행기관 아주대학교
- 지도교수 이범진
- 발행년도 2021
- 학위수여년월 2021. 8
- 학위명 석사
- 학과 및 전공 일반대학원 약학과
- 실제URI http://www.dcollection.net/handler/ajou/000000031166
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
In this study, web address (URL) encoded orodispersible film was designed and printed by Hot melt extruding method using air-pressure based 3D printer. This film contained a poorly water-soluble drug, Paliperidone Palmitate (PPP). This research aimed to determine manufacturing conditions with a high recognition rate (%) and formulation which can disintegrate immediately and have increased solubility. The film was formed by optimizing the ratio of polyethylene oxide (PEO), poloxamer 188, polyethylene glycol (PEG) 4000, and polysorbate 20, Citric acid, and PPP. Nozzle diameter, printing rate, pressure value, printing temperature, and aging time were controlled to print the surface evenly and the QR code in detail. QR code recognition rate (%) of the optimized formulation (F4) was 96.67±2.89%. Physicochemical properties were evaluated by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), and X-ray Diffraction (XRD). The dissolution test was performed under the USP Apparatus type II method in pH 1.2 buffer solution with 0.489% polysorbate 20. Drug-loaded URL-QRODF was recognizable by a smartphone camera. The recognition rate (%) was 96.67±2.89%, which was high enough for daily life. Drug release from the film immediately reached more than 85% and the disintegration time was 17.3±0.7 seconds which means ‘orodispersible’. Patient-centered drug-loaded URL-QRODF that can be connected to any network was devised.
more목차
1. Introduction 1
2. Materials and Methods 6
2.1. Materials 6
2.2. Preparation of URL-ODF by Hot melt extruding 3D printer 6
2.2.1. Preparation of URL recognizing QR coded ODF by 3D printer 6
2.2.2. Formulation of URL recognizing QR coded ODF 8
2.2.3. Manufacturing factors optimization 8
2.3. Characterization of URL recognizing QR coded ODF 16
2.3.1. Recognition rate (%) evaluation 16
2.3.2. Surface pH measurement 16
2.3.3. Film Thickness and Tensile strength measurement 16
2.3.4. Disintegration test 17
2.3.5. Drug content 17
2.3.6. In vitro Dissolution test 17
2.3.7. HPLC analysis 17
2.3.8. SEM (Scanning Electron Microscopy) 18
2.3.9. DSC (Differential Scanning Calorimetry) 18
2.3.10. XRD (X-Ray Diffraction) 18
3. Results and discussions 20
3.1. Manufacturing conditions optimization 20
3.2. Formulation optimization 23
3.3. Characterization of QR recognizing URL ODF 27
3.3.1. Physical characterization 27
3.3.2. In vitro dissolution test 30
3.3.3. Scanning electron microscopy (SEM) 30
3.3.4. Differential scanning calorimetry (DSC) 30
3.3.5. X-ray diffraction (XRD) 30
4. Conclusions 38
5. References 39
