Preparation of URL-recognizing QR-coded Orodispersible Film Using 3D Printing
- 주제(키워드) 3D printing , Hot melt extrusion , Orodispersible film , QR code , Paliperidone palmitate
- 주제(DDC) 615.1
- 발행기관 아주대학교
- 지도교수 이범진
- 발행년도 2021
- 학위수여년월 2021. 8
- 학위명 석사
- 학과 및 전공 일반대학원 약학과
- 실제URI http://www.dcollection.net/handler/ajou/000000031166
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
목차
1. Introduction 1
2. Materials and Methods 6
2.1. Materials 6
2.2. Preparation of URL-ODF by Hot melt extruding 3D printer 6
2.2.1. Preparation of URL recognizing QR coded ODF by 3D printer 6
2.2.2. Formulation of URL recognizing QR coded ODF 8
2.2.3. Manufacturing factors optimization 8
2.3. Characterization of URL recognizing QR coded ODF 16
2.3.1. Recognition rate (%) evaluation 16
2.3.2. Surface pH measurement 16
2.3.3. Film Thickness and Tensile strength measurement 16
2.3.4. Disintegration test 17
2.3.5. Drug content 17
2.3.6. In vitro Dissolution test 17
2.3.7. HPLC analysis 17
2.3.8. SEM (Scanning Electron Microscopy) 18
2.3.9. DSC (Differential Scanning Calorimetry) 18
2.3.10. XRD (X-Ray Diffraction) 18
3. Results and discussions 20
3.1. Manufacturing conditions optimization 20
3.2. Formulation optimization 23
3.3. Characterization of QR recognizing URL ODF 27
3.3.1. Physical characterization 27
3.3.2. In vitro dissolution test 30
3.3.3. Scanning electron microscopy (SEM) 30
3.3.4. Differential scanning calorimetry (DSC) 30
3.3.5. X-ray diffraction (XRD) 30
4. Conclusions 38
5. References 39
