Association between relative handgrip strength and osteoporosis in older women
- 주제(키워드) older adults , relative hand grip strength , osteoporosis , Korea National Health and Nutrition Examination Survey
- 발행기관 아주대학교
- 지도교수 이윤환
- 발행년도 2021
- 학위수여년월 2021. 2
- 학위명 박사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000030810
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
The aim of this study was to identify the association between relative handgrip strength (RHGS) and osteoporosis (OS) in women aged over 60 years in Korea. We used data of 4,179 elderly women retrieved from the Korea National Health and Nutrition Examination Survey (KNHANES) 2014–2018. Binomial logistic regression was used to identify associations between RHGS and OS, controlling for covariates such as age; socioeconomic status; smoking status; alcohol consumption; laboratory test results; and prevalence of hypertension, diabetes mellitus, thyroid disease, and obesity. For statistical analyses, we used IBM SPSS Statistics 22.0. RHGS was found to be significantly associated with OS in older Korean women. Specifically, RHGS of the left hand in the second quartile (Q2) and the fourth quartile (Q4) was inversely associated with the prevalence of OS in female participants aged 60–69 years (Q2: odds ratio [OR] = 0.637; 95% confidence interval [CI], 0.452–0.898; p = 0.010 and Q4: OR = 0.496; 95% CI, 0.258–0.956; p = 0.036), but not in those aged ≥ 70 years. Among women aged 60–69, OS was significantly associated with left hand RHGS after adjusting for sociodemographic characteristics, lifestyle behaviors, and other health-related variables. In contrast, RHGS was not significantly associated with OS in those aged ≥ 70 years. This inconsistency according to age group and right or left hand dominance limits the conclusion of a significant association between OS and RHGS.
more목차
1. Introduction 1
A.Necessity 1
B. Prevalence of osteoporosis in Korea 2
C. Research Questions 2
2. Background 3
A. Osteoporosis 3
B. Pathology and epidemiology of osteoporosis 4
C. Relative handgrip strength 6
D. Handgrip strength and osteoporosis 7
E. Osteoporosis and osteoporosis-related fractures 9
F. Handgrip strength-related factors 10
G. Association between osteoporosis and handgrip strength 12
H. Summary 13
3. Materials and Methods 14
A. Study population 14
B. Eligibility Criteria 14
C. Main Variables 15
1. Osteoporosis 15
2. Relative Hand Grip Strength 15
D. Covariates 17
E. Statistical Analysis 18
4. Results 19
A. Subject Characteristics 19
B. Comparison of clinical outcomes for those with and without OS in the 60–69 and 70+ age groups 21
C. Regression analysis for the association between RHGS and OS in the 60–69 and 70+ age groups 22
D. RHGS cut-off values for OS 25
5. Discussion 27
6. Conclusion 35
References 36
