Biosignal Data Collection Platform Design and Deep Learning-based Data Analytics for Intensive Care Units
- 주제(키워드) biosignal , intensive care unit , data collection platform , deep learning , electrocardiogram
- 발행기관 아주대학교
- 지도교수 윤덕용
- 발행년도 2021
- 학위수여년월 2021. 2
- 학위명 박사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000030696
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Patients in intensive care unit (ICU) have high disease severity and mortality. In addition, the demand for ICUs is expected to increase significantly in an aging society. Therefore, there is an urgent need for research to improve the quality of care for ICU patients. However, owing to the lack of medical personnel in ICUs and financial problems in operation, there is a lack of a system for the real time monitoring of critically ill patients as well as an emergency situation prediction system; accordingly, digital solutions are required to provide care to critically ill patients. In this study, we built a platform that can automatically collect the biosignal data in near real time from multiple patient monitors in the ICUs of the Ajou University Hospital. Data collection methods of patient monitors were classified into three types (Nihon Kohden, Philips, and GE) according to the data export protocols. Therefore, three biosignal collection systems were developed and a unified database was constructed. We also developed a high accuracy ECG (electrocardiogram) delineator (QT detector) through deep learning for single-lead ECG data collected using this platform and verified the utility of this platform by applying it to an index for the weaning outcome. A platform that can automatically collect the biosignal data from approximately 200 patient monitors in near real time was established, and a database of approximately 30,000 critically ill patients was constructed. The U-Net-based ECG delineator developed in this study exhibited high performance by recording a score of 11.6, and detrended fluctuation analysis revealed that the QTc time series of the weaning failure group demonstrated higher complexity. The biosignal data collection platform provides an important data source for monitoring critically ill patients and for performing clinical research to improve the prognosis of ICU patients; it is expected that the platform can be used as a tool to discover medical knowledge related to biosignals that has not yet been revealed.
more목차
I. Introduction 1
A. Background 1
1. Intensive care unit (ICU) 1
2. Biosignal 4
3. Machine learning 5
B. Purpose of the study 7
II. Methods 8
A. Data collection system development 8
1. Patient monitors 8
2. Hardware/Software interfaces 9
3. Database construction 23
B. Verification and utilization of the platform 25
1. Development of deep learning models for ECG delineation 25
2. An example for clinical application: QT-weaning study 52
C. Programming tools 61
III. Results 69
A. Biosignal data collection platform 69
B. Biosignal database 75
C. Deep learning-based ECG delineator 78
D. The results of QT-weaning study 80
IV. Discussion 82
V. Conclusion 87
References 88
국문요약 92
