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쥐 모델에서 저출력 레이저 치료를 이용한 효과적인 상처치유를 위한 최적의 플루언스 및 치료기간에 대한 연구

Optimal Fluence and Duration of Low-Level Laser Therapy for Efficient Wound Healing in Mice

초록/요약

Background/Purpose: Low-level laser (light) therapy is a promising technology that stimulates healing, relieves pain and inflammation, and restores function in injured body parts. However, few studies have compared the effects of light-emitting diodes of different fluence levels or different treatment durations. Here, we investigated the effects of various fluence levels and treatment durations on wound closure in mice. Methods: Full-thickness wounds were created on the dorsal skin using an 8-mm diameter punch, and the wounds were irradiated at 1, 4, or 40 J/cm2 for 5 consecutive days starting on day 1. To determine the optimal irradiation duration, wounds were irradiated at the most potent fluence of previous study for 5, 10 or 15 days. Photographic documentation, skin biopsies, and wound measurements were performed to compare the effects of different treatment parameters. Results: The most effective fluence level was 40 J/cm2, as determined by monitoring wound closure. There were no statistically significant differences in wound healing with different durations. Conclusion: We have shown that repeated exposure to low levels of light significantly stimulates wound healing in mice, and demonstrated more efficient wound closure with certain fluences of 830 nm irradiation.

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목차

1. INTRODUCTION 1
2. MATERIAL AND METHODS 2
2.1 Animal selection and care 2
2.2 Wound creation and LED irradiation 2
2.3 Photo documentation and wound closure analysis 2
2.4 Statistical analysis 3
3. RESULTS 4
3.1 Effect of LED irradiation fluence on wound closure 4
3.2 Effect of the duration of LED irradiation on wound closure 6
4. DISCUSSION 9
5. CONCLUSION 11
6. REFERENCES 12
7. 국문요약 14

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