Development of Pattern Analysis System for Hydrazine Detection using Azo-Based Turn-on Fluorescent Array System
Development of Pattern Analysis System for Hydrazine Detection using Azo-Based Turn-on Fluorescent Array System
- 주제(키워드) Hydrazine , Fluorescent array , Azo
- 발행기관 아주대학교
- 지도교수 김은하
- 발행년도 2020
- 학위수여년월 2020. 2
- 학위명 석사
- 학과 및 전공 일반대학원 분자과학기술학과
- 실제URI http://www.dcollection.net/handler/ajou/000000029764
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Hydrazine is a transparent liquid with a molecular structure of N2H4 that is useful in industrial field, such as synthesis of pharmaceuticals, pesticides and textile dyes and also used component of a rocket fuel. However, hydrazine is a toxic and carcinogenic molecule regulated by the U.S. Environmental Protection Agency. Fluorescence technology which has several advantages, such as convenient measurement, machine-independence, and short detection time, had been introduced. A number of fluorogenic probes, which can discrimination hydrazine, were reported. However, previous study of hydrazine detection systems had been concentrated on using a single probe. Therefore, we focus on an array system to increase the hydrazine discrimination power. Herein, we developed SF-Azo 01, 02, 03 and 04 using the Seoul-Fluor (9-aryl-1,2-dihydropyrrolo[3,4-b]indolizine-3-one) system and azo moiety, which can be a quencher and chemo-reactive site. SF-Azo shows significant fluorescent enhancement and selectivity upon hydrazine. Furthermore, SF-Azo was applied in cellulose paper to develop a fluorescent array system and this system demonstrate successful hydrazine recognition and assaying hydrazine concentration.
more목차
1. Introduction
1.1. Necessity of hydrazine detection
1.2. Array system for detection
1.3. Seoul-Fluor(9-aryl-1,2-dihydropyrrolo[3,4-b]indolizine-3-one)
1.4. Azo moiety
1.5. Aim of thesis
2. Materials and methods
2.1. Materials and compound characterization
2.2. Synthetic procedure of new compounds
2.3. Measurements of photophysical properties of SF-Azo
2.4. hydrazine detection fluorescent array
3. Results and discussions
3.1. Design of hydrazine detection probe using Azo as chemo-reactive moiety
3.2. SF-Azo 01-04 Spectral changes according to reaction with hydrazine
3.3. Selectivity assay for hydrazine
3.4. Hydrazine recognition paper array system
4. Conclusion
References
APPENDIX
ABSTRACT (IN KOREAN)
