성인 중증천식 환자에서 생체지표로서 혈청 EDN 수치의 유용성
Serum level of eosinophil-derived neurotoxin: a biomarker for asthma severity in adult asthmatics
- 주제(키워드) eosinophil-derived neurotoxin , severe asthma , biomarker
- 발행기관 아주대학교
- 지도교수 박해심
- 발행년도 2019
- 학위수여년월 2019. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000028659
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Background: Severe asthma is a refractory disease with complex and heterogeneous pathophysiologic mechanisms. Eosinophilic inflammation is considered a key component of severe asthma (SA). However, there has been no reliable biomarker representing the eosinophilic inflammation of SA. Objective: This study aimed to characterize the clinical features of SA and to evaluate whether serum eosinophil-derived neurotoxin (EDN) level may predict the eosinophilic inflammation of SA in adult asthmatics. Methods: Severe asthmatics (n = 235) and nonsevere asthmatics (n = 898) were enrolled from Ajou University Hospital, South Korea. Serum levels of EDN and periostin (type 2 inflammatory biomarkers) were measured using ELISA, and their association with clinical parameters was analyzed. Results: Severe asthmatics were older and had longer disease durations with significantly lower levels of FEV1% pred and methacholine PC20. Total eosinophil count (TEC) and sputum eosinophil count (%) were significantly higher in severe asthmatics than in nonsevere asthmatics. Serum EDN level and serum periostin level were significantly higher in severe asthmatics than in nonsevere asthmatics (P < 0.034 and P < 0.001, respectively). Correlations of serum EDN level to TEC (r = 0.319, P < 0.001) and to serum periostin level (r = 0.302, P < 0.001) were noted in total asthmatics. Conclusion: These findings suggest that serum EDN level can be a useful biomarker for predicting the phenotype of SA in adult asthmatics.
more목차
I. Introduction
II. Materials and Methods
A. Study Subjects
B. Measurement of Eosinophilic Biomarkers
C. Statistical Analysis
III. Results
A. Demographic and Clinical Characteristics
B. Associations between Clinical Parameters
IV. Discussion
V. Conclusion
References
국문요약
