과민성 장 증후군 환자에서 일반 식품 항원에 대한 식품 특이적 혈청 IgG4 역가의 차이
Alterations of Food-Specific Serum IgG4 Titers to Commom Food Antigens in Patients with Irritable Bowel Syndrome
- 주제(키워드) Food , Irritable bowel syndrome , Immunoglobulin G
- 발행기관 아주대학교
- 지도교수 Kwang Kae Lee
- 발행년도 2018
- 학위수여년월 2018. 8
- 학위명 박사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000027784
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
The role of dietary factors in the pathogenesis of IBS is still unclear. The aim of this study was to compare IgG4 levels to common food antigens between patients with IBS and healthy controls. Thirty-two patients diagnosed as IBS according to Rome III criteria (12 diarrhea subtype; 20 non-diarrhea subtype) and 32 sex and age-matched healthy controls participated in the study. Serum IgG4 titers to 90 common foods were measured in each subject. The number of subjects with positivity defined as the cut-off value ≥ 0.7 U/mL was compared. Patients with IBS had significantly higher IgG4 titers to wheat, leek, and taro compared to those of controls. Serum IgG4 titers to ginger, cocoa, walnut, white radish, onion, and lettuce in IBS patients tended to be higher than controls. IgG4 titers to wheat, gluten and gliadin in the diarrhea subgroup, and lettuce, leek, and taro in the non-diarrhea subgroup tended to be higher, compared with controls. The number of subjects with positivity to apple, orange, lettuce, and leek was significantly higher in IBS patients than controls. The number of subjects with positivity to apple, orange, gluten, and gliadin in the diarrhea subgroup, and egg white, pineapple, soybean, lettuce, and leek in the non-diarrhea subgroup was significantly higher, compared with controls. Serum IgG4 antibody levels to some common foods are abnormally elevated in IBS patients. The type of foods with abnormally elevated serum IgG4 titers in the diarrhea subgroup may be different from that in the non-diarrhea subgroup.
more목차
I. INTRODUCTION 1
II. MATERIALS AND METHODS 3
A. Study Subjects and Design 3
B. Measurement of Serum Food Antigen-specific IgG4 Titers 3
C. Sample Size Calculation 6
D. Statistical Methods 6
III. RESULTS 7
A. Subject Characteristics 7
B. Serum IgG4 Titers 9
C. The Number of Subjects With Positivity for Serum Food IgG4 Titers 11
IV. DISCUSSION 13
V. CONCLUSIONS 16
REFERENCES 17
국문요약 20
