Can early removal of central venous catheter influence duration of fever in febrile neutropenic patients with acute myeloid leukemia?
Can early removal of central venous catheter influence duration of fever in febrile neutropenic patients with acute myeloid leukemia?
- 주제(키워드) Central venous catheter , Duration of fever , Neutropenia , Acute myeloid leukemia
- 발행기관 아주대학교
- 지도교수 박준성
- 발행년도 2018
- 학위수여년월 2018. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000027180
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Neutropenia and fever precipitated from the state are very common and fatal problems to the patients with hematologic malignancy, especially acute leukemia. Additionally, febrile neutropenia costs a lot of money, because the patients generally need to be admitted to hospitals and treated by lots of medications like antibiotics and antifungal drugs. This study was designed to find out the factors that can decrease the duration of febrile neutropenia in acute myeloid leukemia patients and focused the impact due to early (i.e. less than 3 weeks) removal of the central venous catheter that inserted to most of acute myeloid leukemia patients receiving chemotherapy. This retrospective study in a single center analyzed the effects of age, gender, body mass index(BMI), type of chemotherapy, presence of baseline fever before chemotherapy, presence of blood stream infection (BSI), insertion site of central venous catheter and early removal of central venous catheter on the duration of fever in acute myeloid leukemia patients with febrile neutropenia. The results were significant in both univariate and multivariate analyses depending on age, type of chemotherapy, presence of baseline fever and especially, early removal of central venous catheter (univariate analysis: p=0.001, multivariate analysis: hazard ratio 0.546, 95% confidence interval 0.368-0.810, p=0.003). So, the physicians treating febrile neutropenic patients with acute myeloid leukemia may need to actively consider early removal of central venous catheter for reducing the duration of febrile neutropenia.
more목차
I. INTRODUCTION 1
II. MATERIALS and METHODS 2
A. Study Population 2
B. Variables of clinical characteristics and experimental definition 2
C. Statistical analysis 3
III. RESULTS 4
A. Characteristics of patients and central catheter insertion cases 4
B. Duration of febrile neutropenia according to the clinical characteristics of central catheter insertion cases 6
IV. DISCUSSION 9
REFERENCES 12
국문요약 15
