백반증 환자에서 엑시머 레이저 치료의 연속 요법과 주기 요법의 효과 비교 연구
Efficacy of conventional continuous vs. cyclic on-off excimer laser treatment in vitiligo
- 주제(키워드) vitiligo , excimer laser , UVB treatment , cyclic treatment , melanocyte exhaustion
- 발행기관 아주대학교
- 지도교수 강희영
- 발행년도 2017
- 학위수여년월 2017. 8
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000025498
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
OBJECTIVE: To compare the efficacy of conventional continuous excimer laser treatment and cyclic on-off scheduled excimer laser treatment in vitiligo. DESIGN: A randomized, controlled, split-body, non-inferiority study. SETTING: The trial was performed in two tertiary health care centers in Korea. PARTICIPANTS: 12 patients (16 pairs of lesions) with bilateral and symmetrically distributed vitiligo and whose disease duration was less than 5 years. The patients taking systemic steroids or having enlarging lesions were excluded. All of 12 patients completed the study. INTERVENSIONS: All lesions were treated twice weekly by excimer laser for a total of 9-month trial period: continuously in group A, or cyclically with 2-month treatment and 1-month intermission every 3 month (total 3 cycles during the trial) in group B. Topical tacrolimus 0.1% ointment was equally applied to both groups throughout the trial. MAIN OUTCOMES AND MEASURES: Photographic documentation of lesions was conducted every month and the final degree of repigmentation of each group was assessed with a repigmentation rate (%) by using image analysis software. The non-inferiority margin was set at 10%. RESULTS: The mean difference of repigmentation rate between group A and B was 2.194% and the 95% confidence interval (-4.982% to 9.370%) was lower than the non-inferiority margin (10%). In group B, neither loss of repigmentation nor worsening of the vitiligo lesions was observed during intermission. CONCLUSIONS AND RELEVANCE: The cyclic on-off excimer laser treatment was as effective as the continuous excimer laser treatment in vitiligo. It can be a new treatment strategy for vitiligo without deteriorating the disease.
more목차
INTRODUCTION 1
MATERIAL AND METHODS 2
A. Study design and population 2
B. Treatment protocol 2
C. Assessment and primary outcome 2
D. Statistical analysis 3
RESULTS 4
A. Patient characteristics 4
B. Repigmentation rate of continuous and cyclic on-off excimer laser treatments 4
C. Clinical changes during intermission period in cyclic on-off protocol 7
DISCUSSION 8
CONCLUSION 10
REFERENCES 11
국문요약 13
