Alberta Stroke Program Early CT Score (ASPECTS)을 통한 심정지 후 환자들의 조기 신경학적 예후 예측
The Alberta Stroke Program Early CT Score (ASPECTS) for Early Outcome Prediction in Post-Cardiac Arrest Patients
- 주제(키워드) post cardiac arrest , computed tomography
- 발행기관 아주대학교
- 지도교수 홍지만
- 발행년도 2017
- 학위수여년월 2017. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000024887
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
We aimed to evaluate the prognostic performance of bilateral ASPECTS (ASPECTS-b) to predict neurologic outcome in post cardiac arrest patients treated with targeted temperature management (TTM). We conducted a retrospective study of post cardiac arrest patients treated with TTM in two tertiary hospitals. The ASPECTS-b and GWR on brain computed tomography (CT) achieved within 6 hours of return of spontaneous resuscitation (ROSC) was measured twice from each institute. ROC curve analysis of ASPECTS-b and comparison of the ROC curve from each institute was done to assess the performance in predicting poor neurologic outcome (CPC 3-5). A total of 66 patients from institute A and 109 patients from institute B was studied. Of the total of 175 patients enrolled, 117 patients (66.9%) had poor neurologic outcome. ASPECTS-b showed good prognostic performance to predict poor neurologic outcome [AUROC 0.72 (0.64-0.80)] and was not significantly different between institutes [institute A vs. institute B, AUROC 0.83 (95%CI 0.72-0.94) vs. AUROC 0.73(95%CI 0.64-0.83), p=0.2]. ASPECTS-b measured from initial brain CT not only expressed good performance in predicting poor neurologic outcomes in post cardiac arrest patients, but showed similar performances between two different institutes.
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ABSTRACT i
TABLE OF CONTENTS ii
LIST OF FIGURES iii
LIST OF TABLES iv
Ⅰ. INTRODUCTION 1
Ⅱ. MATERIALS AND METHODS 2
A. Study outline 2
B. Data collection 2
C. Measurement of Bilateral ASPECTS and GWR on brain computed tomography 3
D. Targeted temperature treatment and post cardiac arrest treatment 5
E. Statistical analysis 5
Ⅲ. RESULTS 6
A. Baseline characteristics of study subjects 6
B. ASPECTS and GWR on brain CT from both institutes 7
C. ROC curve analysis 8
Ⅳ. DISCUSSION 11
Ⅴ. CONCLUSION 13
REFERENCES 14-15
SUPPLEMENT 16-18
국문요약 19
