교감신경 활성도의 차이에 따른 하부요로 증상의 차이
Differences in Lower Urinary Tract Symptoms between Sympathetic Hyperactive and Hypoactive men
- 주제(키워드) prostatic hyperplasia , autonomic nervous system , lower urinary tract symptoms , heart rate variability
- 발행기관 아주대학교
- 지도교수 최종보
- 발행년도 2015
- 학위수여년월 2015. 8
- 학위명 박사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000020300
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Purpose Heart rate variability (HRV) is a tool used to measure autonomic nervous function; however, there is no evidence that it can be used to define sympathetic hyperactivity in men with lower urinary tract symptoms (LUTS). I suspected that LUTS would differ between sympathetic hyperactive and hypoactive patients. Therefore, I measured HRV and divided the LUTS patients into two groups, a sympathetic hyperactive group and a sympathetic hypoactive group according to the low frequency/high frequency (LF/HF) ratio and made clinical comparisons between the groups. Materials and methods A total of 43 patients with symptomatic LUTS [International Prostate Symptom Score (IPSS) over 8] and 49 healthy volunteers were enrolled. No subjects had diseases that could affect the autonomic nervous system, such as diabetes or hypertension. Electrocardiographic signals were obtained from subjects in the resting state and HRV indexes were calculated with spectral analyses. I divided the LUTS patients into two groups by an LF/HF ratio of 1.9, which was the median value in the healthy volunteers, and compared the differences in clinical characteristics, IPSS, prostate-specific antigen (PSA), and transrectal ultrasound (TRUS) results. The parameters were compared by independent sample t-test by use of SPSS version 19. Results There were no significant differences in age, serum PSA, or volume of the prostate between the 2 LUTS groups. The comparative results for parameters of HRV between the two groups showed only frequency on the IPSS questionnaire to differ significantly. (p<0.05) Conclusion I suggest that an imbalance of autonomic nervous system activity may be a factor and LUTS patients with hypoactive sympathetic tone may suffer from frequency and storage symptoms.
more목차
I. INTRODUCTION 1
II. MATERIALS AND METHODS 2
A. HRV measurement 2
B. Statistical Analysis 3
III. RESULTS 4
IV. DISCUSSION 7
V. CONCLUSIONS 10
REFERENCES 11
국문요약 14
