비외상성 비압박성 척수병에서 만성통증의 양상 및 신경병성 통증 발생의 예측인자
Chronic Pain after Non-traumatic, Non-compressive Myelopathy: Characteristics and Predictors for Neuropathic pain
- 주제(키워드) Chronic pain , Non-traumatic non-compressive myelopathy , Neuropathic pain , Predictors
- 발행기관 아주대학교
- 지도교수 주인수
- 발행년도 2015
- 학위수여년월 2015. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000019496
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Introduction: Chronic pain is one of the most common and serious consequences of myelopathy. The aim of this study was to survey chronic pain experience in a neurology out-patient clinic and to determine potential predictors for neuropathic pain after non-traumatic, non-compressive(NTNC) myelopathy. Methods: We analyzed54 patients with a history of NTNC myelopathy at the neurology out-patient clinic. All patients completed questionnaires on pain severity, descriptors and impact on quality of life (QOL) and underwent neurologic examination with bedside sensory testing. The Short Form McGill Pain Questionnaire (SF-MPQ) and the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) were used to assess pain. Neuropathic pain was diagnosed by LANSS score of 12 or more. Health-related QOL was evaluated by the Short Form 36-item (SF-36) health survey, while Hospital Anxiety and Depression Scale (HADS) and Patient Global Impression of Change (PGIC) were utilized to evaluate emotion and response to treatment for pain, respectively. Results: Out of 54 patients, 48 reported pain; of these, 41 (85.4%) reported the initiation of pain during the first 3 months of myelopathy onset. The median (min-max) pain duration and SF-MPQ score was 41 (3.4-166) months and 10 (1-34), respectively. Thirty five (72.9%) patients reported continuous pain throughout the day. The most common pain descriptions were exhausting, gnawing and heavy. In total, 16 (33.3%) patients experienced neuropathic pain. Mean age was statistically significantly lower in patients with neuropathic pain than in patients with non-neuropathic pain (39.1 ± 12.5 vs. 49.8 ± 9.3, P = 0.002). A binary logistic regression revealed that onset age under 40, non-idiopathic etiologysuch as neuromyelitis optica, multiple sclerosis were independent predictors of the occurrence of neuropathic pain. Both SF-MPQ and LANSS scores were significantly correlated with SF-36 scores, adjusted by age, sex, presence of diabetes mellitus, and current EDSS scores (r = –0.624, P< 0.0001 for SF-MPQ; r = -0.357, P = 0.017 for LANSS). Patients who showed clinical improvement (PGIC scores >2) with treatment were female, non-idiopathic etiology or lengthy lesion (> 3 vertebral segments). But the presence of diabetes was related to a poor treatment response. Conclusion: Chronic pain is one of annoying complications in patients with NTNC myelopathy and also affects their quality of life. Onset age and etiology of myelopathyare important factors in the development of neuropathic pain in NTNC myelopathy. Pain relief research is expected to improve health-related QOL in these patients..
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ABSTRACT ⅰ
TABLE OF CONTENTS ⅲ
LIST OF FIGURES ⅳ
LIST OF TABLES ⅴ
Ⅰ. INTRODUCTION 1
Ⅱ. MATERIAL AND METHOD 3
A. SUBJECTS 3
B. MYELOPATHY CHARACTERISTICS 3
C. PAIN ASSESSMENT 3
D. ASSESSMENT OF FUNCTIONAL AND EMOTIONAL STATUS 4
E. PAIN RESPONSE TO TREATMENT 4
F. STATISTICAL ANALYSIS 5
Ⅲ. RESULTS 6
A. GENERAL CHARACTERISTICS OF SUBJECTS WITH NON-TRAUMATIC, NON-COMPRESSIVE MYELOPATHY 6
B. PAIN PROFILES 6
C. PAIR-WISE COMPARISONS BETWEEN NOCICEPTIVE AND NEUROPATHIC PAIN GROUPS 7
D. PREDICTORS FOR NEUROPATHIC PAIN 7
E. PAIN EFFECT ON QUALITY OF LIFE 8
F. PAIN RESPONSE TO TREATMENT 8
Ⅳ. DISCUSSION 9
Ⅴ. CONCLUSION 15
REFERENCES 30
국문요약 36
