방사성 요오드 치료를 받은 분화성 갑상선암 환자의
Significance of Salivary Gland Radioiodine Retention on Post-ablation 131I Scintigraphy as a Predictor of Salivary Gland Dysfunction in Patients with Differentiated Thyroid Carcinoma
- 주제(키워드) Radioiodine therapy , Salivary gland dysfunction , Differentiated thyroid cancer , I-131 scintigraphy , Salivary gland scintigraphy
- 발행기관 아주대학교
- 지도교수 윤준기
- 발행년도 2014
- 학위수여년월 2014. 8
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000017394
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
- ABSTRACT - Significance of Salivary Gland Radioiodine Retention on Post-ablation 131I Scintigraphy as a Predictor of Salivary Gland Dysfunction in Patients with Differentiated Thyroid Carcinoma Purpose: We investigated whether 131I whole-body scintigraphy could predict functional changes in salivary glands after radioiodine therapy. Methods: We evaluated 90 patients who received initial high-dose (≥3.7 GBq) radioiodine therapy after total thyroidectomy. All patients underwent diagnostic (DWS) and post-ablation (TWS) 131I whole-body scintigraphy. Visual assessment of salivary radioiodine retention on DWS and TWS was used to divide the patients into two types of groups: a DWS+or DWS-group and a TWS+or TWS-group. Salivary gland scintigraphy was also performed before DWS and at the first follow-up visit. Peak uptake and %washout were calculated in ROIs of each gland. Functional changes (Δuptake or Δwashout) of salivary glands after radioiodine therapy were compared between the two groups. Results: Both peak uptake and the %washout of the parotid glands were significantly lower after radioiodine therapy (all p values <0.001), whereas only the %washout were significantly reduced in the submandibular glands (all p values <0.05). For the parotid glands, the TWS+ group showed larger Δuptake and Δwashout after radioiodine therapy than did the TWS- group (all p values <0.01). In contrast, the Δuptake and Δwashout of the submandibular glands did not significantly differ between the TWS+ and TWS- groups (all p values >0.05). Likewise, no differences in Δuptake or Δwashout were apparent between the DWS+ and DWS- groups in either the parotid or submandibular glands (all p values >0.05). Conclusion: Salivary gland radioiodine retention on post-ablation 131I scintigraphy is a good predictor of functional impairment of the parotid glands after high-dose radioiodine therapy.
more목차
ABSTRACT ⅰ
TABLE OF CONTENTS ⅲ
LIST OF FIGURES ⅳ
LIST OF TABLES ⅴ
Ⅰ. Introduction 1
Ⅱ. Materials and Methods 4
A. Subjects 4
B. Radioiodine Treatment Protocol 5
C. Acquisition and Image Analysis of Salivary Gland Scintigraphy 6
D. Acquisition and Image Analysis of 131I Whole-Body Scintigraphy 8
E. Statistical Analysis 9
Ⅲ. Results 10
A. Characteristics of Patients 10
B. Salivary Gland Function 11
C. Radioiodine Retention on 131I Whole-Body Scintigraphy 12
D. Relation between Radioiodine Retention and Salivary Gland Function 13
Ⅳ. Discussion 16
V. Conclusion 22
References 23
국문요약 26
