기능성 소화 불량증 및 과민성 장 증후군의 중복 증후군 환자에서 G-Protein Beta3 C825T 유전자 다형성
G-Protein Beta3 Subunit C825T Polymorphism in Patients With Overlap Syndrome of Functional Dyspepsia and Irritable Bowel Syndrome
- 주제(키워드) Functional dyspepsia , Irritable bowel syndrome , G-protein beta3 subunit
- 발행기관 아주대학교
- 지도교수 이광재
- 발행년도 2012
- 학위수여년월 2012. 8
- 학위명 석사
- 학과 및 전공 일반대학원 의학계열
- 실제URI http://www.dcollection.net/handler/ajou/000000012706
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Background: G-protein beta3 subunit (GNB3) C825T polymorphism alters intracellular signal transduction, which may lead to motor or sensory abnormalities of the gastrointestinal tract. The aim of the present study was to evaluate the association of the GNB3 C825T polymorphism with susceptibility to overlap syndrome of functional dyspepsia (FD) and irritable bowel syndrome (IBS) in a Korean population. Methods: One hundred sixty-seven patients with FD alone, 60 patients with IBS alone, 85 patients with the overlap of FD and IBS, and 434 asymptomatic healthy subjects participated in the study. Genotyping for GNB3 C825T polymorphism was performed using their blood samples. Results: No association of genotype in subjects with FD alone, IBS alone or overlap phenotype compared to that in controls was detected. The frequency of GNB3 C825T CT and TT genotypes relative to the CC genotype for the phenotypes of FD alone, IBS alone, and the coexistence of FD and IBS did not significantly differ. Comparison of the TT genotype with the CC/CT genotype showed no significant association for each phenotype group. Conclusions: There is no apparent association of the GNB3 C825T polymorphism with the susceptibility to FD, IBS or the overlap of FD and IBS. A larger-scale study and further investigation on other candidate genes are required.
more목차
I. INTRODUCTION 1
II. MATERIALS AND METHODS 2
A. Study subjects 3
B. Questionnaire 3
C. Genotyping 3
D. Statistical analysis 4
III. RESULTS 5
IV. DISCUSSION 9
V. CONCLUSION 12
REFERENCES 13
국문요약 16
