높은 이완성을 갖는 새로운 시스템의 MR 조영제: 가돌리늄을 담지한 메조다공 실리카 코어/쉘
Development of New system for High T1-relaxivity MR Contrast Agent: Gadolinium incorporated Mesoporous Silica Core/Shell
- 주제(키워드) 조영제 , 가돌리늄 , 실리카
- 발행기관 아주대학교
- 지도교수 김상욱
- 발행년도 2012
- 학위수여년월 2012. 2
- 학위명 석사
- 학과 및 전공 일반대학원 분자과학기술학과
- 실제URI http://www.dcollection.net/handler/ajou/000000012169
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
New system of gadolinium based nanoparticles for T1-MR contrast agents which have high T1-relaxivity was developed. It showed non-aggregated, biocompatible properties and no release of free Gd3+ ions. The structure of non-aggregated MSHS/Gd2O3@pAA system was elucidated by TEM and SEM. The specific relaxivities, r1 and r2 values, of the MSHS/Gd2O3@pAA are measured by 4.9T MR scanner, which are higher than those of the commercial Gadovist. Gd3+ ion releasing experiment was conducted by measuring an amount of leached Gd3+, which showed a trace of ions was released. The cytotoxicity of MSHS/Gd2O3@pAA was examined on MDA-MB 435S cells, which showed no appreciable toxicity in the cells.
more목차
Cover page ________________________________________1
Approval page _____________________________________3
Acknowledgements ________________________________4
Abstract ___________________________________________5
Table of Contents __________________________________6
List of Scheme ____________________________________7
List of Figures _____________________________________8
Introduction _______________________________________9
Experimental Section ______________________________11
Results and Discussion ____________________________15
Conclusions ______________________________________18
Scheme __________________________________________19
Figure ____________________________________________20
References _______________________________________28
