Alfentanil과 remifentanil 정주 후 나타나는 기침의 발생 빈도와 정도 비교
Comparison of the Incidence and Severity of Cough after Alfentanil and Remifentanil Injection
- 주제(키워드) alfentanil , remifentanil , opioid induced cough
- 발행기관 아주대학교
- 지도교수 이숙영
- 발행년도 2011
- 학위수여년월 2011. 2
- 학위명 박사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000011484
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Introduction: Intravenous administration of fentanyl derivatives can induce cough paradoxically. This study examined the incidence and severity of cough after a bolus of alfentanil and remifentanil. Methods: Four-hundred sixty five patients, aged 18-70 years, were allocated randomly to three groups to receive alfentanil 10 μg/kg, remifentanil 1 μg/kg, or an equal volume of 0.9% saline intravenously over 10 s. Any episode of cough was classified as coughing and graded as mild (1-2), moderate (3-4) or severe (5 or more). Results: The overall incidence of cough was higher in the opioid groups than the saline group. The remifentanil group [39/150 patients; 26.0%, (95% CI, 19.6-33.6%)] showed a higher incidence than the alfentanil group [11/152 patients; 7.2%, (95% CI, 0.4-12.6%)] (P < 0.001). There was no significant difference in the severity of cough between alfentanil and remifentanil group. Conclusion: This study demonstrated that the equipotent boluses of alfentanil and remifentanil induced coughing, even though the incidence of cough after alfentanil administration was lower than that after remifentanil administration.
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ABSTRACT i
TABLE OF CONTENTS ii
LIST OF TABLES iii
LIST OF FIGURE iv
ABBREVIATIONS v
I. INTRODUCTION 1
II. PATIENTS AND METHODS 3
III. RESULTS 5
IV. DISCUSSION 12
REFERENCES 17
국문요약 21
