저신장증 소아에서 체질량 지수가 성장호르몬
Influence of Body Mass Index on Growth Hormone Responses to Classic Provocative Tests in Children with Short Stature
- 주제(키워드) Body mass index , Growth hormone , Short stature
- 발행기관 아주대학교
- 지도교수 황진순, 배기수, 정조원
- 발행년도 2011
- 학위수여년월 2011. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000011196
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Objective: Growth hormone (GH) secretion is regulated by physiological parameters. Obesity is associated with diminished spontaneous and stimulated GH secretion. The aim of this study was to assess the influence of BMI on growth hormone response to provocative testing in children with short stature. Materials and methods: Clinical data was collected retrospectively by chart review from the Pediatric Endocrine Unit at Ajou University Hospital. A total of 187 subjects with short stature who completed a GH stimulation testing between 2003 and 2009 were included in the study. Results: The study population included 123 (65.8%) males and 64 (34.2%) females with a mean age of 8.5 ± 2.9 years. Of the 187 subjects, 66 (35.3%) had GH deficiency (serum peak GH <10 ng/ml), while 121 (64.7%) were categorized as having idiopathic short stature (serum peak GH ≥ 10 ng/ml). In a stepwise multivariate analysis, BMI was a significantly independent predictor of peak GH. Elevated BMI was negatively associated with peak plasma GH levels. Conclusion: Higher BMI is associated with lower GH secretion. BMI should be measured and GH results appropriately interpreted for all subject undergoing GH stimulation testing.
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ABSTRACT i
TABLE OF CONTENTS ii
LIST OF FIGURES iii
LIST OF TABLES iv
I. INTRODUCTION 1
II. MATERIALS AND METHODS 2
A. SUBJECTS 2
B. STUDY DESIGN 2
C. LABORATORY MEASUREMENTS 3
D. STATISTICAL ANALYSIS 4
III. RESULTS 5
A. SUBJECTS CHARACTERISTICS 5
B. COMPARISON OF GH RESPONSES OF INSULIN VS. DOPAMINE AND
CLONIDINE 5
C. DETERMINANTS OF PEAK GROWTH HORMONE RESPONSE TO
PHARMACOLOGICAL TESTS 6
PHARMACOLOGICAL TESTS 6
D. RELIABILITY OF TESTS 6
IV. DISCUSSION 12
V. CONCLUSION 15
REFERENCES 16
국문요약 21
