근치적 신요관전적출술을 시행받은 상부요로 이행세포암에서 예후인자
Prognostic Factors in Transitional Cell Carcinoma of Upper Urinary Tract after Radical Nephroureterectomy
- 주제(키워드) Urinary tract cancer , Transitional cell carcinoma , Prognosis
- 발행기관 아주대학교
- 지도교수 김세중
- 발행년도 2011
- 학위수여년월 2011. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 파일정보 한글 2007
- 실제URI http://www.dcollection.net/handler/ajou/000000011184
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Purpose : The aim of this study was to evaluate the prognostic factors for survival in patients treated surgically for transitional cell carcinoma of the upper urinary tract (UUT-TCC). Materials and Methods : I retrospectively reviewed the medical records of 87 patients (64 men and 23 women, mean age of 62.2 years) with UUT-TCC who had undergone radical nephroureterectomy at our institution between June 1994 and June 2009. The median follow-up period was 32 months. The prognostic significance of various clinicopathological variables for recurrence-free and cancer-specific survival was analyzed using univariate and multivariate analysis. Results : Of total 87 patients, 21 patients (24.1%) developed local recurrence or distant metastasis and 16 patients (18.4%) died during the follow-up period. The 5-year recurrence-free and cancer-specific survival rates were 74.6% and 75.2%, respectively. On univariate analysis, hydronephrosis, T stage, N stage, and lymphovascular invasion (LVI) were significant prognostic factors for recurrence-free and cancer-specific survival. On multivariate analysis, T stage and LVI were independent prognostic factors for recurrence-free and cancer-specific survival. Conclusions : The T stage and LVI are independent prognostic factors for recurrence-free and cancer-specific survival in patients with UUT-TCC treated by radical nephroureterectomy. These findings would be helpful for guiding the decisions about adjuvant therapies and surveillance interval.
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ABSTRACT ⅰ
TABLE OF CONTENTS ⅲ
LIST OF TABLES iv
Ⅰ. INTRODUCTION 1
Ⅱ. MATERIALS AND METHODS 2
Ⅲ. RESULTS 4
Ⅳ. DISCUSSION 9
Ⅴ. CONCLUSION 14
REFERENCES 15
국문요약 19
목차
Table 1. Clinicopathological data of the 87 patients included in the study 4
Table 2. Univariate and multivariate analysis of potential prognostic factors for recurrence-free survival 6
Table 3. Univariate and multivariate analysis of potential prognostic factors for cancer-specific survival 8
