자궁내막증식증 및 자궁내막암과 syndecan-1의 발현과의 관련성
The Expression of Syndecan-1 is Related to the Risk of Endometrial Hyperplasia Progressing to Endometrial Carcinoma
- 주제(키워드) Syndecan-1 , 자궁내막증식증 , 자궁내막암
- 발행기관 아주대학교
- 지도교수 유희석
- 발행년도 2010
- 학위수여년월 2010. 8
- 학위명 박사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000010928
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Objective: Aberrant expression of the cell surface proteoglycan, syndecan-1, is found in many malignancies. The current study describes the immunohistochemical study of syndecan-1 expression in normal, hyperplastic, and malignant endometrial tissues for evaluation of application as a parameter of cancer progression in patients with endometrial hyperplasia. Methods: Immunohistochemical staining of syndecan-1 was performed in 101 formalin fixed, paraffin embedded sections of normal, hyperplastic, and malignant endometrial tissues. We analyzed specimens from patients with normal endometrium (NE, n=10) as controls, and those of simple hyperplasia (SH, n=20), complex hyperplasia without atypia (CH, n=20), atypical hyperplasia (AH, n=20), and endometrial cancer (EC, n=31). Results: The mean rank of expression scores based on the frequency of syndecan-1 staining were 31.6, 20.5, 52.9, 72.1, and 62.1 for NE, SH, CH, AH and EC, respectively (p < 0.001). Syndecan-1 expression was significantly greater in CH (p < 0.001) or AH (p < 0.001) than in SH, and significantly greater in AH compared to CH (p=0.028). Syndecan-1 is more frequently expressed in CH (p=0.042), AH (p < 0.001), or EC (p=0.002) than in NE. Syndecan-1 expression did not differ significantly between NE and SH (p=0.248). Conclusion: Syndecan-1 expression appears to be useful as a predictive indicator of endometrial carcinogenesis from normal endometrium or endometrial hyperplasia to endometrial cancer.
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ABSTRACT ⅰ
TABLE OF CONTENTS ⅲ
LIST OF FIGURES ⅳ
LIST OF TABLES ⅴ
Ⅰ. INTRODUCTION 1
Ⅱ. PATIENTS AND METHODS 3
A. Patients and tissue samples 3
B. Immunohistochemical study 5
C. Staining evaluation 5
D. Statistical analysis 6
Ⅲ. RESULTS 7
A. Patient characteristics 7
B. Expression of syndecan-1 8
Ⅳ. DISCUSSION 12
REFERENCE 15
국문요약 19
