GnRH agonist로 치료한 특발성 진성 성조숙증 여아에서 치료전과 치료 1년 후에 DEXA로 측정한 골밀도와 체성분의 변화
Changes in BMD and Body Composition in Children with Central Precocious Puberty Before and After Treatment with GnRH Agonist
- 주제(키워드) central precocious puberty , GnRH agonist , bone mineral density , obesity , DEXA
- 발행기관 아주대학교
- 지도교수 황진순
- 발행년도 2010
- 학위수여년월 2010. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000010733
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
We assessed bone mineral density (BMD) and body composition in 121 Korean girls with central precocious puberty (CPP) before, during, and after 1 year of treatment with gonadotropin-releasing hormone (GnRH) agonist. BMD, bone mineral content (BMC), lean body mass (LBM), and fat mass (FM) were measured at baseline and after 1 year of treatment with dual energy x-ray absorptiometry (DEXA) and were expressed as standard deviation scores (SDS). Bone age and biochemical and hormonal profiles were assessed at baseline, after 6 months and 1 year of treatment. Mean BMC and LBM were significantly lower than zero at baseline while FM and percent body fat (% FM) were higher than zero at baseline for both chronological and bone age. After 1 year of treatment, the differences for chronological age were decreased while the differences for bone age were persisted. The BMD SDS of each region of interest (ROI) including lumbar spine for chronological age were significantly higher than zero at baseline and increased after 1 year of treatment, while BMD SDS for bone age was significantly lower than zero at baseline and increased after 1 year of treatment. Girls with CPP showed high %FM before and after GnRH agonist treatment for both chronological and bone age. The risk of obesity seems to be started before GnRH agonist treatment. Through this study, we concluded that pituitary-gonadal axis suppression by GnRH agonist does not reverse the progression of bone mass acquisition in children with CPP.
more목차
ABSTRACT i
TABLE OF CONTENTS ii
LIST OF FIGURES iii
LIST OF TABLES iv
ABBREVIATION v
I. INTRODUCTION 1
II. SUBJECTS AND METHODS 3
A. PATIENTS 3
B. METHODS 3
C. STATISTICS 5
III. RESULTS 6
A. POPULATION CHARACTERISTICS 6
B. BONE MINERAL DENSITY CHANGES OF EACH REGION OF INTEREST 7
C. BODY COMPOSITION CHANGES 11
IV. DISCUSSION 12
V. CONCLUSION 16
REFERENCES 17
국문요약 21
