Association of Lamivudine-Resistant Mutational Patterns with the Antiviral Effect of Adefovir in Patients with Chronic Hepatitis B
Association of Lamivudine-Resistant Mutational Patterns with the Antiviral Effect of Adefovir in Patients with Chronic Hepatitis B
- 발행기관 아주대학교
- 지도교수 조성원
- 발행년도 2009
- 학위수여년월 2009. 8
- 학위명 박사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000010011
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
목차
ABSTRACT ⅰ
TABLE OF CONTENTS ⅱ
LIST OF TABLES iii
ABBREVIATION iv
I. INTRODUCTION 1
II. MATERIALS AND METHODS 3
A. Patients 3
B. Blood tests 3
C. Detection of mutations by restriction fragment mass polymorphism (RFMP)
Analysis 5
D. Sequencing analysis 6
E. Definition 6
F. Statistical analysis 7
III.RESULTS 8
A. Virologic and biochemical response to adefovir 8
B. Antiviral efficacy of Adefovir between the HBeAg-positive and -negative
Groups 8
C. Baseline hepatitis B virus polymerase mutations 8
D. Effect of lamivudine-resistant mutational pattern on the virologic and
biochemical response to adefovir 12
IV. DISCUSSION 15
V. CONCLUSION 18
REFERENCES 19
국문요약 24
