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연골 조직에서 저강도 초음파에 의해 발현되는 초기 유전자 분석

Identification of Early Response Genes Affected by Low-Intensity Ultrasound in Rat Cartilage Explant Culture

목차

Abstract--------------ⅰ
Table of Contents-----ⅲ
List of Figures--------ⅵ
List of Table----------ⅴ
Ⅰ. Introduction--------1
Ⅱ. Material & methods---------------------4
1. Explant culture of rat articular cartilage----4
2. LIUS treatment---------------------------5
3. Extraction of total RNA--------------------7
4. Microarray-------------------------------7
Ⅲ. Results ------------9
1. Scatter plot analysis----------------------9
2. Significant gene selection in LIUS treated cartilage explants------------------------------------11
3. K-means clustering results of 1,100 selected genes--13
4. Functional analysis by gene expression profile------15
Ⅳ. Discussion------23
Ⅴ. Conclusion------26
Reference-----------27
국문요약------------33

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