인간 대퇴골 근위부의 3차원적 골소주 미세구조에서 연령에 따른 변화와 부위에 따른 차이
Age-Related Changes and Regional Variations in Three-Dimensional Microstructural Properties of Male Proximal Femoral Trabecular Bone
- 주제(키워드) Aging , Microstructure , Trabeculae , Proximal femur
- 주제(KDC) 510
- 주제(DDC) 610
- 발행기관 아주대학교
- 지도교수 원예연
- 발행년도 2007
- 학위수여년월 2007. 8
- 학위명 박사
- 학과 및 전공 일반대학원 의학과
- 본문언어 영어
초록/요약
Purpose: The purpose of this study was therefore to explore regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging. Materials and Methods: A total of 162 trabecular bone cores were obtained from six regions (femoral head, superior and inferior regions of the neck, and superior/middle and inferior regions of the trochanter) of twenty-seven normal femora of Korean male cadaver donors, aged 40-90 years. These specimens were scanned using high-resolution micro-computed tomography (micro-CT). The following 3D microstructural parameters were calculated: bone volume fraction (BV/TV), trabecular thickness (Tb.Th), separation (Tb.Sp) and number (Tb.N), structure model index (SMI) and degree of anisotropy (DOA). Results: The results showed that the trabecular microstructure changed significantly with age, as well as varied from different regions of the proximal femur. There was a significant decrease in bone volume fraction and an almost identical decrease in trabecular thickness associated with aging at any region. Regional analysis demonstrated a significant difference not only in BV/TV, Tb.Th, Tb.Sp, Tb.N, DOA between superior and inferior neck, but also difference in BV/TV, Tb.Sp, Tb.N, SMI, DOA between superior and inferior trochanter. Conclusions: Age-related changes in bone loss and trabecular microstructure within the male proximal femur are not uniform in this Korean cadaveric population. As a result of mechanical and age-related adaptation, significant regional variations in microstructural properties of trabecular bone are likely to be an important factor affecting the mechanical properties of the proximal femur.
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TABLE OF CONTENTS
ABSTRACT ⅰ
TABLE OF CONTENTS ⅲ
LIST OF FIGURES ⅳ
LIST OF TABLES ⅴ
ABBREVIATION ⅵ
Ⅰ. INTRODUCTION 1
Ⅱ. MATERIALS AND METHODS 5
A. Specimen selection and preparation 5
B. Micro-CT imaging 7
C. Statistical Analysis 8
Ⅲ. RESULTS 9
Ⅳ. DISCUSSION 20
Ⅴ. CONCLUSION 27
REFERENCES 28
국문요약 36
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LIST OF FIGURES
Fig. 1. A) The proximal femur was marked to identify three locations: base of the head, the neck-trochanter junction, and the base of the lesser and greater trochanters. B) The specimens were cut to provide three sections per femur, and trabecular cores were obtained from these three bone sections 6
Fig. 2. A-F: Variations in 3D trabecular microstructure in the femoral head (A), the neck superior (B) and inferior regions (C), and the trochanteric superior (D), middle (E) and inferior regions (F) with aging 9
Fig. 3. Changes in microstructural properties of trabecular bone in 6 regions: the femoral head, neck superior and inferior regions, and trochanteric superior, medial and inferior regions 10
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LIST OF TABLES
Table 1. Regression coefficient r values from linear regression analysis for regional variations in 3D microstructural properties of trabecular bone with aging 14
Table 2. Microstructural parameters derived from 6 regions in the three age groups. 15
