Stereoselective Total Syntheses of Musellarins D and E
- 주제(키워드) Dehydrogenative Cycloetherification , cis-2-Alkyl-6-aryl-3 , 6-dihydro-2H-pyran , Diastereoselectivity , Natural Products , Musellarins D and E
- 주제(DDC) 615.1
- 발행기관 아주대학교
- 지도교수 이동주
- 발행년도 2023
- 학위수여년월 2023. 2
- 학위명 석사
- 학과 및 전공 일반대학원 약학과
- 실제URI http://www.dcollection.net/handler/ajou/000000032797
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
The first and unified stereoselective total syntheses of naturally occurring (+)-musellarin D and musellarin E have been accomplished in 8 steps from the readily available α-tetralone, respectively. The key feature of our strategy includes highly diastereoselective dehydrogenative etherification and substrate-controlled benzylic allylation. The relative configuration of both musellarins D and E was revised.
more목차
I. Introduction 1
II. Results and Discussion 3
III. Conclusion 8
IV. Experimental Section 9
1. Materials and Methods 9
2. Full Experimental Procedures and Analytical Data of Compounds 11
V. References 27
VI. Appendix 29
