급성 일산화탄소 중독에서의 에탄올의 신경 보호 효과
Neuroprotective Effect of Ethanol in Acute Carbon Monoxide Intoxication
- 주제(키워드) carbon monoxide , ethanol , brain injury
- 발행기관 아주대학교
- 지도교수 민영기
- 발행년도 2018
- 학위수여년월 2018. 8
- 학위명 박사
- 학과 및 전공 일반대학원 의학과
- 파일정보 최종논문.pdf
- 실제URI http://www.dcollection.net/handler/ajou/000000027800
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
In acute carbon monoxide (CO) intoxication, treatment of neurologic injury and prevention of neurological sequelae are primary concerns. Ethanol is the one of the frequent substances which is co-ingested in intentional CO poisoning. Neuroprotective effect of ethanol was highlighted and demonstrated in isolated brain injury recently. We assessed the neuroprotective effect of ethanol in acute CO intoxication using magnetic resonance imaging (MRI). We retrospectively reviewed medical records for patients who visited an emergency medical center of a university-affiliated hospital during a period of 73 months, from March 2009 to April 2015. Enrolled patients were divided into 2 groups, patients with or without abnormal brain lesion in brain MRI. Multivariate logistic regression analysis was performed to assess the factors associated with brain injury in MRI. A total of 109 patients with acute CO intoxication were evaluated of which 66 (60.55%) tested positive in brain MRI. MRI lesion positive patients were more likely to have electrocardiogram change, elevation of serum troponin I and s100 protein level and lower serum ethanol level. Serum ethanol positivity was an independent factor for prevalence of brain injury in MRI in acute CO poisoning. This study revealed that ethanol which is co-ingested in acute CO intoxication may work the neuroprotective effect and could consequence more favorable neurological outcome in acute CO intoxication.
more목차
Abstract ························································· i
Table of Contents ············································ iii
List of Figure ················································ iv
List of Table ·················································· v
Abbreviation ··················································· vi
I. Introduction ················································· 1
II. Methods ····················································· 5
A. Enrolled patients and study setting ······················ 5
B. Data collection ················································ 8
C. Statistical analysis ··········································· 11
III. Results ····················································· 14
A. Comparison of characteristics ···························· 14
B. Comparison of laboratory results ························ 16
C. Analysis for factors associated with MRI lesions ··· 17
D. Distribution of brain lesions ····························· 19
IV. Discussion ··············································· 20
V. Conclusion ················································ 26
References ····················································· 27
국문요약 ······················································· 32
