아디포넥틴과 내장 지방이 인슐린 감수성과 인슐린 분비능에 미치는 복합 효과
The combined effect of Adiponectin and Visceral fat on Impaired Insulin Sensitivity and Insulin Secretion
- 주제(키워드) Adiponectin level , visceral fat , insulin sensitivity , metabolic syndrome , beta-cell dysfunction
- 발행기관 아주대학교
- 지도교수 김대중
- 발행년도 2018
- 학위수여년월 2018. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000027245
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
1.Objectives: To examine the combined effects of adiponcetin levels and Visceral Adipose Tissue (VAT) mass on the risk of impaired insulin sensitivity and insulin secretion. 2.Methods: This research enrolled 1,347 participants (501 men, 846 women) aged 30 to 64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center of Korea. These participants were stratified into six groups according to combination of the adiponectin level (tertiles) and visceral fat level (< 75 %tile or ≥75 %tile). For each group, odds ratio of insulin sensitivity and insulin secretion ability (beta-cell function) were measured to evaluate their correlation with each other. 3.Results: After adjusting for age, body mass index, hs-CRP, triglyceride, and physical activity, odds ratio[95% confidence interval] for insulin sensitivity (HOMA-IR ≥ 2.5) in groups 2, 3, 4, 5, and 6 compared to the group 1 (highest tertile of adiponectin and VAT < 75%tile) were 2.06 (1.26 – 3.37), 3.31 (2.05 – 5.33), 4.08 (2.00 – 8.35), 5.88 (3.25 – 10.65), and 13.79 (7.65 – 24.83), respectively. Odds ratio (95% CI) for insulin sensitivity (Matsuda index ≤ 25%tile) in groups 2, 3, 4, 5, and 6 compared to group 1 were 1.33 (0.78 – 2.25), 2.60 (1.59 – 4.25), 4.22 (2.05 – 8.67), 4.99 (2.74 – 9.08), and 8.80 (4.91 – 15.78), respectively. Odds ratio (95% CI) for beta-cell dysfunction (HOMA-B% ≤ 25%tile) in groups 2, 3, 4, 5, and 6 compared to group 1 were 0.99 (0.68 – 1.43), 1.43 (0.98 – 2.07), 0.65 (0.29 – 1.42), 1.46 (0.85 – 2.51), and 1.36 (0.80 – 2.31), respectively. Odds ratio (95% CI) for beta-cell dysfunction (insulinogenic index ≤ 25%tile) in groups 2, 3, 4, 5, and 6 compared to group 1 were 0.62 (0.43 – 0.89), 0.86 (0.60 – 1.25), 0.91 (0.46 – 1.78), 1.18 (0.70 – 1.97), and 1.00 (0.60 – 1.64), respectively. 4.Conclusion: This study showed a combined effect of decreasing adiponectin levels and increasing VAT on insulin sensitivity.
more목차
I. INTRODUCTION 1
II. METHODS 3
A.Study Population 3
B.Measurements 3
C.Patient classification and definition 5
D.Statistical Analysis 6
III. RESULTS 7
IV. DISCUSSION 10
V. LIMITATIONS 12
VI. CONCLUSION 13
VII. ACKNOWLEDGEMENT 14
REFERENCES 20
국문 요약 24
